FYB1 - FYN binding protein 1 Gene

Homo sapiens

Also known as FYB; ADAP; THC3; PRO0823; SLAP130; SLAP-130

Gene ID: 2533 | Gene type: protein coding

About FYB1

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:39,105,252-39,274,528 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in appendix (RPKM 36.5), lymph node (RPKM 32.7) and 15 other tissues.

Summary

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FYB1 Products(5)

mRNA	Protein	Name
NM_001243093.2	NP_001230022.1	FYN-binding protein 1 isoform 3
NM_001349333.2	NP_001336262.1	FYN-binding protein 1 isoform 1
NM_001465.6	NP_001456.3	FYN-binding protein 1 isoform 1
NM_018594.2	NP_061064.2	FYN-binding protein 1 isoform 4
NM_199335.5	NP_955367.1	FYN-binding protein 1 isoform 2

FYB1 Protein Structure

SH3_2

hSH3

0
200
400
600
783 a.a.

Protein Preferred Names

Protein Names

FYN-binding protein 1

FYB-120/130

Related Diseases

Diseases

Alias

Thrombocytopenia 3

THC3	Thrombocytopenia, Autosomal Recessive, 3

Congenital Autosomal Recessive Small-Platelet Thrombocytopenia

Carst

Plasmodium Vivax Malaria

Malaria, Vivax	Malaria By Plasmodium Vivax
Vivax Malaria	Malaria Vivax

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Blood Group Incompatibility

Rh Isoimmunization

Rh Incompatibility Affecting Management Of Mother

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency	Rosenthal Syndrome
Pta Deficiency	Hemophilia C
Rosenthal Factor Deficiency	F11 Deficiency
Congenital Factor Xi Deficiency	Hereditary Factor Xi Deficiency Disease
Haemophilia C	Factor Xi Deficiency, Autosomal Dominant
Rosenthal'S Disease	Factor 11 Deficiency
Factor Xi	Factor Xi Deficiency, Autosomal Recessive
Factor Xi Deficiency, Congenital	FA11D
Thromboplastin Antecedent Deficiency	Pta - [Plasma Thromboplastin Antecedent] Deficiency
Congenital Factor Xi Deficiency Disease	Rosenthal Disease

Hemoglobinopathy

Hemoglobinopathies

Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency	Glucose-6-Phosphate Dehydrogenase Deficiency
Deficiency Of Glucose-6-Phosphate Dehydrogenase	Glucose 6 Phosphate Dehydrogenase Deficiency
Deficiency Of G-6pd	G6pdd

Sickle Cell Anemia

Hemoglobin Sc Disease	Anemia, Sickle Cell
Hbsc Disease	Sickle Cell-Hemoglobin C Disease Syndrome
Hb Ss Disease	Sickle Cell Trait
Drepanocytosis	Haemoglobin Sc Disease
Hb Sc Disease	Hb-S/Hb-C Disease
Hb-Ss Disease Without Crisis	Hemoglobin S Disease Without Crisis
Sickle Cell Anaemia	Sickle-Cell/Hb-C Disease Without Crisis
Sickle Cell - Hemoglobin C Disease	Hbs Disease
Hemoglobin S Disease	Sickling Disorder Due To Hemoglobin S
SKCA	Sickle Cell Disease
Sickle Cell-Hemoglobin C Disease	Sickle-Cell Disease Carrier
Sickle-Cell Heterozygous Disorder	Haemoglobin A-S Genotype
Hb-S - [Sickle Cell Haemoglobin] Carrier	Sickle Cell Haemoglobin Trait
As - [Sickle Cell Trait]	Hbas - [Sickle Cell Haemoglobin Trait]
Sickle-Cell Trait Haemoglobin Disease	Haemoglobin Sickle Cell Trait Disorder
Heterozygous Sickle Cell Trait	Hbas - [Heterozygous Haemoglobin S]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05172	FYB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FYB1	VGNC	VGNC:72831
Canis familiaris	FYB1	VGNC	VGNC:41024
Bos taurus	FYB1	VGNC	VGNC:29160
Mus musculus	FYB1	MGD	MGI:1346327
Felis catus	FYB1	VGNC	VGNC:62398
Rattus norvegicus	FYB1	RGD	RGD:1563421

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