Npy5r - neuropeptide Y receptor Y5 Gene

Rattus norvegicus

Also known as NPYR5

Gene ID: 25340 | Gene type: protein coding

About Npy5r

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,343,892-163,352,403 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 33 paralogues.

Summary

Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Located in cytoplasm. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (Neuropeptide Y Receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]

Npy5r Products(2)

mRNA	Protein	Name
NM_012869.2	NP_037001.1	neuropeptide Y receptor type 5
XM_006253014.4	XP_006253076.1	neuropeptide Y receptor type 5 isoform X1

Npy5r Protein Structure

7tm_1

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

neuropeptide Y receptor type 5

NPY-Y5 receptor	NPY5-R
NPYY5-R	Neuropeptide Y5 receptor
Y5 receptor

Related Diseases

Diseases

Alias

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Dihydropyrimidinase Deficiency

Dihydropyrimidinuria	Dpys Deficiency
Dph Deficiency	DPYSD
Dihydrouracil Amidohydrolase Deficiency	Dihydropyrimidinuria Due To Dpys Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107734	L 152804	Antagonist	99.48%	Unkown
HY-RS09520	NPY5R Human Pre-designed siRNA Set A		/	Unkown
HY-RS09521	Npy5r Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09522	Npy5r Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npy5r	NCBI	NCBI:4889

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