2. Gene
  3. CADM2 - cell adhesion molecule 2 Gene

CADM2 - cell adhesion molecule 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2

Gene ID: 253559 | Gene type: protein coding

About CADM2

Cytogenetic location: 3p12.1 Genomic coordinates (GRCh38): 3:84,958,989-86,074,429 (from NCBI)

This gene has 5 transcripts (splice variants), 273 orthologues and 14 paralogues. Biased expression in brain (RPKM 29.4), fat (RPKM 2.4) and 1 other tissue.

Summary

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

CADM2 Products(14)

mRNA Protein Name
NM_001167674.2 NP_001161146.1 cell adhesion molecule 2 isoform 1 precursor
NM_001167675.2 NP_001161147.1 cell adhesion molecule 2 isoform 2 precursor
NM_001256502.2 NP_001243431.1 cell adhesion molecule 2 isoform 4
NM_001256503.2 NP_001243432.1 cell adhesion molecule 2 isoform 4
NM_001256504.2 NP_001243433.1 cell adhesion molecule 2 isoform 5
NM_001256505.2 NP_001243434.1 cell adhesion molecule 2 isoform 5
NM_001375960.1 NP_001362889.1 cell adhesion molecule 2 isoform 6 precursor
NM_001375961.1 NP_001362890.1 cell adhesion molecule 2 isoform 7
NM_001375964.1 NP_001362893.1 cell adhesion molecule 2 isoform 8 precursor
NM_001375967.1 NP_001362896.1 cell adhesion molecule 2 isoform 9 precursor
NM_001375968.1 NP_001362897.1 cell adhesion molecule 2 isoform 10 precursor
NM_001381963.1 NP_001368892.1 cell adhesion molecule 2 isoform 11 precursor
NM_001381964.1 NP_001368893.1 cell adhesion molecule 2 isoform 1 precursor
NM_153184.4 NP_694854.2 cell adhesion molecule 2 isoform 3 precursor

CADM2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (27 - 109)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (140 - 210)

I-set

I-set: Immunoglobulin I-set domain (229 - 313)

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  • 435 a.a.
Protein Preferred Names Protein Names

cell adhesion molecule 2

immunoglobulin superfamily member 4D

Recombinant CADM2 Proteins

Cat. No. Product Name Accession Purity
HY-P75599 CADM2/IGSF4D Protein, Human (HEK293, His) Q8N3J6-2 (G30-D335) ≥95%

Related Diseases

Diseases Alias
Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction
Hallucinogen Dependence

Hallucinogen Addiction
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01820 CADM2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CADM2 VGNC VGNC:70674
Mus musculus CADM2 MGD MGI:2442722
Felis catus CADM2 VGNC VGNC:102609
Rattus norvegicus CADM2 RGD RGD:1305678
Canis familiaris CADM2 VGNC VGNC:38656
Bos taurus CADM2 VGNC VGNC:26695
Others CADM2 NCBI