GAGE1 - G antigen 1 Gene

Homo sapiens

Also known as CT4.1; CT4.4; GAGE4; GAGE-1; GAGE-4

Gene ID: 2543 | Gene type: protein coding

About GAGE1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,599,013-49,608,538 (from NCBI)

This gene has 2 transcripts (splice variants), 30 orthologues and 22 paralogues. Restricted expression toward testis (RPKM 23.5).

Summary

This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GAGE1 Products(1)

mRNA	Protein	Name
NM_001040663.4	NP_001035753.1	G antigen 1

GAGE1 Protein Structure

GAGE

0
100
139 a.a.

Protein Preferred Names

Protein Names

G antigen 1

Cancer/testis antigen 4.4

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05233	GAGE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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