MCM9 - minichromosome maintenance 9 homologous recombination repair factor Gene

Homo sapiens

Also known as ODG4; MCMDC1; C6orf61; dJ329L24.1; dJ329L24.3

Gene ID: 254394 | Gene type: protein coding

About MCM9

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:118,813,455-118,935,159 (from NCBI)

This gene has 9 transcripts (splice variants), 171 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 3.1), lymph node (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

MCM9 Products(19)

mRNA	Protein	Name
NM_001378356.1	NP_001365285.1	DNA helicase MCM9 isoform 1
NM_001378357.1	NP_001365286.1	DNA helicase MCM9 isoform 1
NM_001378358.1	NP_001365287.1	DNA helicase MCM9 isoform 2
NM_001378359.1	NP_001365288.1	DNA helicase MCM9 isoform 3
NM_001378360.1	NP_001365289.1	DNA helicase MCM9 isoform 3
NM_001378361.1	NP_001365290.1	DNA helicase MCM9 isoform 4
NM_001378362.1	NP_001365291.1	DNA helicase MCM9 isoform 4
NM_001378363.1	NP_001365292.1	DNA helicase MCM9 isoform 4
NM_001378364.1	NP_001365293.1	DNA helicase MCM9 isoform 5
NM_001378365.1	NP_001365294.1	DNA helicase MCM9 isoform 6
NM_001378366.1	NP_001365295.1	DNA helicase MCM9 isoform 7
NM_001378367.1	NP_001365296.1	DNA helicase MCM9 isoform 8
NM_001378368.1	NP_001365297.1	DNA helicase MCM9 isoform 9
NM_001378369.1	NP_001365298.1	DNA helicase MCM9 isoform 10
NM_001378370.1	NP_001365299.1	DNA helicase MCM9 isoform 11
NM_001378371.1	NP_001365300.1	DNA helicase MCM9 isoform 12
NM_001378372.1	NP_001365301.1	DNA helicase MCM9 isoform 13
NM_017696.3	NP_060166.2	DNA helicase MCM9 isoform 1
NM_153255.5	NP_694987.1	DNA helicase MCM9 isoform 2

MCM9 Protein Structure

MCM

0
200
400
600
800
1000
1143 a.a.

Protein Preferred Names

Protein Names

DNA helicase MCM9

DNA replication licensing factor MCM9

Related Diseases

Diseases

Alias

Ovarian Dysgenesis 4

46,Xx Ovarian Dysgenesis-Short Stature Syndrome	ODG4
Dysgenesis, Ovarian, Type 4

Premature Ovarian Failure 1

Ovarian Failure, Premature	Fmr1-Related Primary Ovarian Insufficiency
Fragile X-Associated Primary Ovarian Insufficiency	POF1
Pofx	Hypergonadotropic Ovarian Failure, X-Linked
Pof	Primary Ovarian Insufficiency, Fragile X-Associated
Primary Ovarian Insufficiency 1	Ovarian Failure Premature
Premature Ovarian Failure, X-Linked	Fragile X Premature Ovarian Failure
Fmr1-Related Premature Ovarian Failure	Familial Premature Ovarian Failure
Idiopathic Familial Premature Ovarian Failure	Fxpoi
X-Linked Hypergonadotropic Ovarian Failure	Hypergonadotropic Ovarian Failure X-Linked
Poi	Premature Ovarian Failure X-Linked
Primary Ovarian Insufficiency	Premature Ovarian Failure-1
Ovarian Failure, Premature, Type 1	Premature Ovarian Failure, Familial
Premature Menopause	Primary Hypogonadism
Turner Syndrome

Uterine Hypoplasia

Endometrial Mixed Adenocarcinoma

Amenorrhea

Absence Of Menstruation

Amenia

Nondisjunction

Mosaicism, Chromosomal

Mixoploidy, Familial

Meier-Gorlin Syndrome 8

MGORS8

Deafness, Autosomal Dominant 70

DFNA70	Autosomal Dominant Nonsyndromic Deafness 70
Autosomal Dominant Deafness 70	Deafness, Autosomal Dominant, 70

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08242	MCM9 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MCM9	MGD	MGI:1918817
Canis familiaris	MCM9	VGNC	VGNC:43089
Bos taurus	MCM9	VGNC	VGNC:31315
Rattus norvegicus	MCM9	RGD	RGD:1560557
Macaca mulatta	MCM9	VGNC	VGNC:83432
Felis catus	MCM9	VGNC	VGNC:63415