2. Gene
  3. Ptk2 - protein tyrosine kinase 2 Gene

Ptk2 - protein tyrosine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as FAK; FRNK; p125FAK

Gene ID: 25614 | Gene type: protein coding

About Ptk2

Primary_assembly 7: 105,126,728-105,331,783 reverse strand.mRatBN7.2:CM026980.1

This gene has 8 transcripts (splice variants), 230 orthologues, 32 paralogues and is associated with 32 phenotypes. Biased expression in Lung (RPKM 37.3), Kidney (RPKM 29.5) and 9 other tissues.

Summary

Enables several functions, including identical protein binding activity; Integrin binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of cell population proliferation; and regulation of cell migration. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and nuclear lumen. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2 Products(1)

mRNA Protein Name
NM_013081.2 NP_037213.1 focal adhesion kinase 1

Ptk2 Protein Structure

FERM_N_2

FERM_N_2: pfam18038 (78 - 173)

B41

B41: smart00295 (79 - 301)

FERM_C_FAK1

FERM_C_FAK1: cd13190 (297 - 407)

PTKc_FAK

PTKc_FAK: cd05056 (499 - 768)

Focal_AT

Focal_AT: pfam03623 (1003 - 1132)

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  • 1140 a.a.
Protein Preferred Names Protein Names

focal adhesion kinase 1

FADK 1

PTK2 protein tyrosine kinase 2

focal adhesion kinase-related nonkinase

pp125FAK

Related Agents

Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111546 BI-3663 Inhibitor 99.90% Unkown
HY-124625 BI-4464 Inhibitor 99.27% Unkown
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-148063 DB0614 98.80% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-130422 Tos-PEG4-t-butyl ester ≥97.0% Unkown
HY-148061 DB1113 99.28% Unkown
HY-130521 Pomalidomide-amido-PEG3-C2-NH2 99.55% Unkown
HY-136194 TL13-22 Inhibitor / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-RS11399 PTK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11400 Ptk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11401 Ptk2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11402 PTK2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk2 NCBI NCBI:5747