2. Gene
  3. NUDT14 - nudix hydrolase 14 Gene

NUDT14 - nudix hydrolase 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UGPP; UGPPase

Gene ID: 256281 | Gene type: protein coding

About NUDT14

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,172,939-105,181,312 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 8.0), kidney (RPKM 7.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This Enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

NUDT14 Products(2)

mRNA Protein Name
NM_001318380.2 NP_001305309.1 uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2
NM_177533.5 NP_803877.2 uridine diphosphate glucose pyrophosphatase NUDT14 isoform 1

NUDT14 Protein Structure

NUDIX

NUDIX: NUDIX domain (40 - 201)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

uridine diphosphate glucose pyrophosphatase NUDT14

UDP-sugar diphosphatase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16965 TH287 Inhibitor 98.29% Unkown
HY-158318 NUDT5/14 antagonist 1 Inhibitor / Unkown
HY-RS09664 NUDT14 Human Pre-designed siRNA Set A / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NUDT14 VGNC VGNC:80896
Canis familiaris NUDT14 VGNC VGNC:49752
Rattus norvegicus NUDT14 RGD RGD:1310583
Mus musculus NUDT14 MGD MGI:1913424
Bos taurus NUDT14 VGNC VGNC:32328