2. Gene
  3. Hmgcr - 3-hydroxy-3-methylglutaryl-CoA reductase Gene

Hmgcr - 3-hydroxy-3-methylglutaryl-CoA reductase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as 3H3M

Gene ID: 25675 | Gene type: protein coding

About Hmgcr

Primary_assembly 2: 27,997,525-28,019,703 reverse strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 206 orthologues and is associated with 39 phenotypes. Biased expression in Liver (RPKM 17.6), Brain (RPKM 11.7) and 9 other tissues.

Summary

Enables identical protein binding activity and protein Phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Located in intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcr Products(1)

mRNA Protein Name
NM_013134.2 NP_037266.2 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Hmgcr Protein Structure

2A060605

2A060605: TIGR00920 (10 - 896)

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  • 897 a.a.
Protein Preferred Names Protein Names

3-hydroxy-3-methylglutaryl-coenzyme A reductase

HMG-CoA reductase

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17504 Rosuvastatin Calcium 99.77% Yes
HY-119695A Simvastatin acid ammonium Inhibitor 99.69% Unkown
HY-17504B Rosuvastatin Sodium 99.85% Yes
HY-115292 Simvastatin hydroxy acid sodium Inhibitor ≥99.0% Unkown
HY-119695 Simvastatin acid Inhibitor / Unkown
HY-119695B Simvastatin acid calcium hydrate Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15483 DY131 99.88% Unkown
HY-107855 DL-Mevalonolactone ≥98.0% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 98.76% Unkown
HY-106281 Bemfivastatin Inhibitor 99.48% Unkown
HY-17504R Rosuvastatin Calcium (Standard) 99.94% Unkown
HY-114316 HMG499 Inhibitor / Unkown
HY-101873S Atorvastatin lactone-d5 Inhibitor / Unkown
HY-116241 L-157012 Inhibitor / Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-N11637 Ganoderenic acid K Inhibitor / Unkown
HY-RS06238 HMGCR Human Pre-designed siRNA Set A / Unkown
HY-RS06239 Hmgcr Mouse Pre-designed siRNA Set A / Unkown
HY-RS06240 Hmgcr Rat Pre-designed siRNA Set A / Unkown
HY-119695AS1 Simvastatin acid-d9 ammonium Inhibitor / Unkown
HY-17504BS2 Rosuvastatin-13C,d3 sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcr NCBI NCBI:3156