SLC24A2 - solute carrier family 24 member 2 Gene

Homo sapiens

Also known as NCKX2

Gene ID: 25769 | Gene type: protein coding

About SLC24A2

Cytogenetic location: 9p22.1-p21.3 Genomic coordinates (GRCh38): 9:19,507,455-20,307,892 (from NCBI)

This gene has 2 transcripts (splice variants), 288 orthologues and 4 paralogues. Restricted expression toward brain (RPKM 17.5).

Summary

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

SLC24A2 Products(4)

mRNA	Protein	Name
NM_001193288.3	NP_001180217.1	sodium/potassium/calcium exchanger 2 isoform 2
NM_001375850.1	NP_001362779.1	sodium/potassium/calcium exchanger 2 isoform 1
NM_001375851.1	NP_001362780.1	sodium/potassium/calcium exchanger 2 isoform 2
NM_020344.4	NP_065077.1	sodium/potassium/calcium exchanger 2 isoform 1

SLC24A2 Protein Structure

Na_Ca_ex

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

sodium/potassium/calcium exchanger 2

Na(+)/K(+)/Ca(2+)-exchange protein 2

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 5

Familial Temporal Lobe Epilepsy 5	ETL5
Epilepsy, Temporal Lobe, Familial, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13085	SLC24A2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC24A2	RGD	RGD:628650
Mus musculus	SLC24A2	MGD	MGI:1923626
Macaca mulatta	SLC24A2	VGNC	VGNC:77425
Felis catus	SLC24A2	VGNC	VGNC:65249
Bos taurus	SLC24A2	VGNC	VGNC:34737
Canis familiaris	SLC24A2	VGNC	VGNC:46286

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