1. Gene
  2. GALR1 - galanin receptor 1 Gene

GALR1 - galanin receptor 1 Gene

Homo sapiens

Also known as GALNR; GALNR1

Gene ID: 2587 | Gene type: protein coding

About GALR1

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:77,249,848-77,277,900 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 1.2), brain (RPKM 0.7) and 7 other tissues.

Summary

The neuropeptide Galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

GALR1 Products(1)

mRNA Protein Name
NM_001480.4 NP_001471.2 galanin receptor type 1

GALR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 303)

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  • 349 a.a.
Protein Preferred Names Protein Names

galanin receptor type 1

GAL1-R

Related Diseases

Diseases Alias
Chromosome 18q Deletion Syndrome

18q- Syndrome

Monosomy 18q

Deletion Of Long Arm Of Chromosome 18

Chromosome 18q- Syndrome

Deletion 18q

18q Deletion Syndrome

Distal 18q Deletion Syndrome

Chromosome 18 Long Arm Deletion Syndrome

Chromosome 18q Monosomy

Del Syndrome

Chromosome 18 Deletion Syndrome

Auditory Agnosia
Benign Essential Hypertension
Mood Disorder

Mood Disorders

Episodic Mood Disorder

Lynch Syndrome I

Lynch Syndrome 1

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

HNPCC1

Fcc1

Lynch Syndrome Ii

Colon Cancer, Familial Nonpolyposis, Type 1

Coca1

Familial Nonpolyposis Colon Cancer Type 1

Hereditary Nonpolyposis Colorectal Cancer Type 1

Hereditary Non-Polyposis Colorectal Cancer 1

Hereditary Non-Polyposis Colorectal Cancer 3

Hnpcc3

Lynch Cancer Family Syndrome

Lynch Syndrome

Lynch Syndrome Type I

Lynch Syndrome Type Ii

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1

Hereditary Nonpolyposis Colorectal Cancer

Colorectal Cancer, Hereditary Nonpolyposis, Type 3

Hereditary Non-Polyposis Colon Cancer Type 2

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus GALR1 VGNC VGNC:29239
Canis familiaris GALR1 VGNC VGNC:41100
Macaca mulatta GALR1 VGNC VGNC:104222
Mus musculus GALR1 MGD MGI:1096364
Rattus norvegicus GALR1 RGD RGD:2656
Felis catus GALR1 VGNC VGNC:62456