ADGRA2 - adhesion G protein-coupled receptor A2 Gene

Homo sapiens

Also known as TEM5; GPR124

Gene ID: 25960 | Gene type: protein coding

About ADGRA2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,796,883-37,844,896 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 42 paralogues. Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in positive regulation of canonical Wnt signaling pathway. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2022]

ADGRA2 Products(1)

mRNA	Protein	Name
NM_032777.10	NP_116166.9	adhesion G protein-coupled receptor A2 precursor

ADGRA2 Protein Structure

LRR_8

HRM

GPS

7tm_2

0
300
600
900
1200
1338 a.a.

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor A2

G-protein coupled receptor 124

Recombinant ADGRA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78977	TEM5/GPR124 Protein, Human (HEK293, His)	AAO27354 (A27-R359)	≥95%

Related Diseases

Diseases

Alias

Kidney Leiomyosarcoma

Leiomyosarcoma Of Kidney

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00343	ADGRA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADGRA2	VGNC	VGNC:69453
Mus musculus	ADGRA2	MGD	MGI:1925810
Felis catus	ADGRA2	VGNC	VGNC:59628
Bos taurus	ADGRA2	VGNC	VGNC:106631
Rattus norvegicus	ADGRA2	RGD	RGD:2323365
Canis familiaris	ADGRA2	VGNC	VGNC:37632

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