PLEKHG3 - pleckstrin homology and RhoGEF domain containing G3 Gene

Homo sapiens

Also known as ARHGEF43; KIAA0599

Gene ID: 26030 | Gene type: protein coding

About PLEKHG3

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,704,424-64,750,249 (from NCBI)

This gene has 10 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in endometrium (RPKM 8.9), kidney (RPKM 8.6) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHG3 Products(1)

mRNA	Protein	Name
NM_001308147.2	NP_001295076.1	pleckstrin homology domain-containing family G member 3

PLEKHG3 Protein Structure

RhoGEF

0
200
400
600
800
1000
1219 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family G member 3

PH domain-containing family G member 3

Related Diseases

Diseases

Alias

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome	Bcd Syndrome
Elschnig Syndrome	Clefting, Ectropion, And Conical Teeth
Lagophthalmia With Bilateral Cleft Lip And Palate	Blepharo-Cheilo-Odontic Syndrome
Bcds	Ectropion, Inferior, With Cleft Lip And/Or Palate
Blepharo-Cheilo-Dontic Syndrome	BCDS1
Ectropion Inferior Cleft Lip And Or Palate	Clefting-Ectropion-Conical Teeth Syndrome
Ectropion Inferior-Cleft Lip And/Or Palate Syndrome	Lagophthalmia-Cleft Lip And Palate Syndrome
Blepharocheilodontic Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10691	PLEKHG3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLEKHG3	VGNC	VGNC:33016
Macaca mulatta	PLEKHG3	VGNC	VGNC:76082
Rattus norvegicus	PLEKHG3	RGD	RGD:1308089
Felis catus	PLEKHG3	VGNC	VGNC:64228
Canis familiaris	PLEKHG3	VGNC	VGNC:44678
Mus musculus	PLEKHG3	MGD	MGI:2388284

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