OSBPL3 - oxysterol binding protein like 3 Gene

Homo sapiens

Also known as ORP3; ORP-3; OSBP3

Gene ID: 26031 | Gene type: protein coding

About OSBPL3

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:24,796,537-24,981,845 (from NCBI)

This gene has 14 transcripts (splice variants), 276 orthologues and 11 paralogues. Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 23 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin Cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

OSBPL3 Products(4)

mRNA	Protein	Name
NM_015550.4	NP_056365.1	oxysterol-binding protein-related protein 3 isoform a
NM_145320.2	NP_663160.1	oxysterol-binding protein-related protein 3 isoform b
NM_145321.2	NP_663161.1	oxysterol-binding protein-related protein 3 isoform c
NM_145322.2	NP_663162.1	oxysterol-binding protein-related protein 3 isoform d

OSBPL3 Protein Structure

PH_8

Oxysterol_BP

0
200
400
600
800
887 a.a.

Protein Preferred Names

Protein Names

oxysterol-binding protein-related protein 3

OSBP-related protein 3

Related Diseases

Diseases

Alias

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis	Erythrokeratodermia Variabilis Et Progressiva
Greither Disease	Ekv
Ekvp	PSEK
Erythrokeratodermia Variabilis With Erythema Gyratum Repens	Keratosis Palmoplantaris Transgrediens Et Progrediens
Transgrediens Et Progrediens Palmoplantar Keratoderma	EKVP1
Erythrokeratodermia, Progressive Symmetric	Erythrokeratodermia Figurata, Congenital Familial, In Plaques
Keratoderma Palmoplantaris Transgrediens	Keratosis Extremitatum Hereditaria Progrediens
Erythrokeratodermia Variabilis, Mendes Da Costa Type	Progressive Symmetric Erythrokeratodermia
Erythrokeratodermia Figurata Variabilis	Greither'S Disease
Ekv-P	Erythrokeratodermia Variabilis Of Mendes Da Costa
Progressive Symmetrical Erythrokeratoderma Of Gottron	Progressive Diffuse Ppk
Progressive Diffuse Palmoplantar Keratoderma	Transgrediens Et Progrediens Ppk
Darier-Gottron Disease	Erythrokeratodermia Progressiva Symmetrica
Progressive Symmetric Erythrokeratodermia, Gottron Type	Congenital Familial Erythrokeratodermia Figurata In Plaques
Erythrokeratodermia Progressive Symmetric	Erythrokeratodermia Variabilis Mendes Da Costa Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09841	OSBPL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OSBPL3	VGNC	VGNC:63979
Canis familiaris	OSBPL3	VGNC	VGNC:44155
Bos taurus	OSBPL3	VGNC	VGNC:32462
Rattus norvegicus	OSBPL3	RGD	RGD:1564287
Mus musculus	OSBPL3	MGD	MGI:1918970
Macaca mulatta	OSBPL3	VGNC	VGNC:75623

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