NOC2L - NOC2 like nucleolar associated transcriptional repressor Gene

Homo sapiens

Also known as NIR; NET7; NET15; PPP1R112

Gene ID: 26155 | Gene type: protein coding

About NOC2L

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:944,203-959,256 (from NCBI)

This gene has 6 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in testis (RPKM 23.1), skin (RPKM 20.4) and 25 other tissues.

Summary

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of Histone Acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

NOC2L Products(1)

mRNA	Protein	Name
NM_015658.4	NP_056473.3	nucleolar complex protein 2 homolog

NOC2L Protein Structure

Noc2

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

nucleolar complex protein 2 homolog

NOC2-like protein

Related Diseases

Diseases

Alias

Epiphyseal Chondrodysplasia, Miura Type

ECDM	Tall Stature-Scoliosis-Macrodactyly Of The Great Toes Syndrome
Miura Type Epiphyseal Chondrodysplasia	Tall Stature-Scoliosis-Macrodactyly Of The Halluces Syndrome
Tall Stature-Long Halluces-Multiple Extra-Epiphyses Syndrome	Chondrodysplasia, Epiphyseal, Miura Type

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09400	NOC2L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NOC2L	VGNC	VGNC:63845
Bos taurus	NOC2L	VGNC	VGNC:32146
Canis familiaris	NOC2L	VGNC	VGNC:43873
Rattus norvegicus	NOC2L	RGD	RGD:1309387
Mus musculus	NOC2L	MGD	MGI:1931051
Macaca mulatta	NOC2L	VGNC	VGNC:75245

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