INTS1 - integrator complex subunit 1 Gene

Homo sapiens

Also known as INT1; NET28; NDCAGF

Gene ID: 26173 | Gene type: protein coding

About INTS1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,470,277-1,504,389 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 20.1), kidney (RPKM 10.8) and 25 other tissues.

Summary

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS1 Products(1)

mRNA	Protein	Name
NM_001080453.3	NP_001073922.2	integrator complex subunit 1

INTS1 Protein Structure

DUF3677

0
400
800
1200
1600
2000
2190 a.a.

Protein Preferred Names

Protein Names

integrator complex subunit 1

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Cataracts, Poor Growth, And Dysmorphic Facies

NDCAGF

Meier-Gorlin Syndrome 4

MGORS4

Meier-Gorlin Syndrome, Type 4

Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome	Brachymelic Primordial Dwarfism
Cephaloskeletal Dysplasia	Low-Birth-Weight Dwarfism With Skeletal Dysplasia
Microcephalic Osteodysplastic Primordial Dwarfism Type I	Osteodysplastic Primordial Dwarfism Type I
Primordial Microcephalic Dwarfism, Crachami Type	Osteodysplastic Primordial Dwarfism, Type 1
MOPD1	Mopd I
Mopd	Osteodysplastic Primordial Dwarfism, Type I
Tals	Microcephalic Osteodysplastic Primordial Dwarfism Type 1
Mopd 1	Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii	Mopd Types I And Iii
Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type	Primordial Microcephalic Dwarfism Crachami Type
Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06850	INTS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INTS1	RGD	RGD:1308908
Bos taurus	INTS1	VGNC	VGNC:30223
Felis catus	INTS1	VGNC	VGNC:62937
Canis familiaris	INTS1	VGNC	VGNC:42045
Macaca mulatta	INTS1	VGNC	VGNC:81336
Mus musculus	INTS1	MGD	MGI:1915760

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