FBXO2 - F-box protein 2 Gene

Homo sapiens

Also known as FBG1; FBX2; Fbs1; OCP1; NFB42

Gene ID: 26232 | Gene type: protein coding

About FBXO2

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,648,387-11,654,429 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 5 paralogues. Biased expression in brain (RPKM 27.1), adrenal (RPKM 10.3) and 11 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

FBXO2 Products(1)

mRNA	Protein	Name
NM_012168.6	NP_036300.2	F-box only protein 2

FBXO2 Protein Structure

F-box-like

FBA

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

F-box only protein 2

F-box gene 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04797	FBXO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FBXO2	VGNC	VGNC:49675
Rattus norvegicus	FBXO2	RGD	RGD:621751
Bos taurus	FBXO2	VGNC	VGNC:28897
Mus musculus	FBXO2	MGD	MGI:2446216
Macaca mulatta	FBXO2	VGNC	VGNC:72486
Felis catus	FBXO2	VGNC	VGNC:107540

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