2. Gene
  3. FBXO6 - F-box protein 6 Gene

FBXO6 - F-box protein 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FBG2; FBS2; FBX6; Fbx6b

Gene ID: 26270 | Gene type: protein coding

About FBXO6

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,664,200-11,674,354 (from NCBI)

This gene has 3 transcripts (splice variants), 97 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

FBXO6 Products(1)

mRNA Protein Name
NM_018438.6 NP_060908.1 F-box only protein 6

FBXO6 Protein Structure

F-box-like

F-box-like: F-box-like (13 - 60)

FBA

FBA: F-box associated region (75 - 258)

  • 0
  • 100
  • 200
  • 293 a.a.
Protein Preferred Names Protein Names

F-box only protein 6

F-box protein FBG2

Related Diseases

Diseases Alias
Ngly1-Deficiency

Deficiency Of N-Glycanase 1

Ngly1-Cddg

Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome

Ngly1 Deficiency

Congenital Disorder Of Deglycosylation

Congenital Disorder Of Glycosylation Type Iv

Congenital Disorder Of Deglycosylation

Cddg

Congenital Disorder Of Glycosylation Type Iv

Cdg1v
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04812 FBXO6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FBXO6 MGD MGI:1354743
Bos taurus FBXO6 VGNC VGNC:28918
Rattus norvegicus FBXO6 RGD RGD:620418
Canis familiaris FBXO6 VGNC VGNC:40788
Macaca mulatta FBXO6 VGNC VGNC:72490
Felis catus FBXO6 VGNC VGNC:62197