2. Gene
  3. Fto - fat mass and obesity associated Gene

Fto - fat mass and obesity associated Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mKIAA1752

Gene ID: 26383 | Gene type: protein coding

About Fto

Chromosome 8: 92,040,153-92,395,067 forward strand.GRCm39:CM001001.3

This gene has 7 transcripts (splice variants), 202 orthologues and is associated with 54 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 3.4) and 28 other tissues.

Summary

Enables DNA-N1-methyladenine dioxygenase activity; oxidative DNA demethylase activity; and oxidative RNA demethylase activity. Involved in several processes, including nucleic acid metabolic process; regulation of respiratory system process; and regulation of white fat cell proliferation. Located in nucleus. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and salivary gland. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Fto Products(1)

mRNA Protein Name
NM_011936.2 NP_036066.2 alpha-ketoglutarate-dependent dioxygenase FTO

Fto Protein Structure

FTO_NTD

FTO_NTD: pfam12933 (35 - 321)

FTO_CTD

FTO_CTD: cl15176 (325 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

fat mass and obesity-associated protein

m6A(m)-demethylase FTO

mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

mRNA N(6)-methyladenosine demethylase FTO

protein fatso

tRNA N1-methyl adenine demethylase FTO

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14280 Entacapone Inhibitor 99.92% Yes
HY-B1320 Meclofenamic acid sodium Inhibitor 99.86% Unkown
HY-101082 N6,2′-O-Dimethyladenosine Inhibitor 99.93% Unkown
HY-117275 Meclofenamic acid Inhibitor 98.60% Unkown
HY-117275A Meclofenamic acid sodium hydrate Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-127103 FB23-2 Inducer 99.93% Unkown
HY-137187 FB23 98.66% Unkown
HY-N6769 Radicicol Inhibitor 99.63% Unkown
HY-151106 FTO-IN-8 Inhibitor 98.03% Unkown
HY-145238 FTO-IN-6 98.94% Unkown
HY-132865 FTO-IN-3 99.79% Unkown
HY-149334 ZLD115 Inhibitor 99.24% Unkown
HY-147011 FTO-IN-7 Inhibitor 99.22% Unkown
HY-138843A FTO-IN-1 TFA 98.04% Unkown
HY-14280S Entacapone-d10 Inhibitor ≥98.0% Unkown
HY-RS05137 Fto Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-117275S Meclofenamic acid-d4 Inhibitor / Unkown
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / Unkown
HY-117426 MO-I-500 Inhibitor / Unkown
HY-132863 FTO-IN-2 / Unkown
HY-138843 FTO-IN-1 / Unkown
HY-139820 FTO-IN-4 / Unkown
HY-139821 FTO-IN-5 / Unkown
HY-156405 FTO-IN-10 / Unkown
HY-N10340 Clausine E Inhibitor / Unkown
HY-RS05136 FTO Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05138 Fto Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-131871 Ethyl LipotF Inhibitor / Unkown
HY-W588293 3-Methylthymidine / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fto NCBI NCBI:79068