2. Gene
  3. Map2k1 - mitogen-activated protein kinase kinase 1 Gene

Map2k1 - mitogen-activated protein kinase kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mek1; MEKK1; MAPKK1; Prkmk1

Gene ID: 26395 | Gene type: protein coding

About Map2k1

Chromosome 9: 64,093,052-64,160,913 reverse strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 22 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 5.3), cortex adult (RPKM 32.1) and 27 other tissues.

Summary

Enables MAP kinase kinase activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and neurogenesis. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to colocalize with microtubule. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map2k1 Products(2)

mRNA Protein Name
NM_008927.5 NP_032953.1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1
NM_001410474.1 NP_001397403.1 dual specificity mitogen-activated protein kinase kinase 1 isoform 2

Map2k1 Protein Structure

PKc_MEK1

PKc_MEK1: cd06650 (61 - 379)

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  • 393 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 1

ERK activator kinase 1

MAP kinase kinase 1

MAPK/ERK kinase 1

protein kinase, mitogen activated, kinase 1, p45

Recombinant Map2k1 Proteins

Cat. No. Product Name Accession Purity
HY-P73825 MEK1 Protein, Mouse (sf9, His-GST) P31938 (M1-I393) ≥95%
HY-P73826 MEK1 Protein, Mouse (sf9) P31938 (N-G&P, M1-I393) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-152860 Darizmetinib Inhibitor 98.92% Unkown
HY-RS08033 MAP2K1 Human Pre-designed siRNA Set A / Unkown
HY-RS08034 Map2k1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08035 Map2k1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k1 NCBI NCBI:5604