PLEK2 - pleckstrin 2 Gene

Homo sapiens

Gene ID: 26499 | Gene type: protein coding

About PLEK2

Cytogenetic location: 14q23.3-q24.1 Genomic coordinates (GRCh38): 14:67,386,984-67,412,165 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 16.6), small intestine (RPKM 14.3) and 17 other tissues.

Summary

The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin Cytoskeleton to induce cell spreading. In conjunction with Complement Component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]

PLEK2 Products(1)

mRNA	Protein	Name
NM_016445.3	NP_057529.1	pleckstrin-2

PLEK2 Protein Structure

DEP

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

pleckstrin-2

pleckstrin 2 homolog

Related Diseases

Diseases

Alias

Ecthyma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10678	PLEK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLEK2	VGNC	VGNC:33002
Rattus norvegicus	PLEK2	RGD	RGD:1305786
Mus musculus	PLEK2	MGD	MGI:1351466
Macaca mulatta	PLEK2	VGNC	VGNC:76071
Canis familiaris	PLEK2	VGNC	VGNC:51670
Felis catus	PLEK2	VGNC	VGNC:64215

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