INTS6 - integrator complex subunit 6 Gene

Homo sapiens

Also known as HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2

Gene ID: 26512 | Gene type: protein coding

About INTS6

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:51,334,405-51,453,036 (from NCBI)

This gene has 20 transcripts (splice variants), 189 orthologues and 11 paralogues. Broad expression in testis (RPKM 13.0), thyroid (RPKM 3.7) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

INTS6 Products(4)

mRNA	Protein	Name
NM_001039937.2	NP_001035026.1	integrator complex subunit 6 isoform b
NM_001039938.2	NP_001035027.1	integrator complex subunit 6 isoform c
NM_001306091.2	NP_001293020.1	integrator complex subunit 6 isoform 4
NM_012141.3	NP_036273.1	integrator complex subunit 6 isoform a

INTS6 Protein Structure

VWA_2

INT_SG_DDX_CT_C

0
200
400
600
800
887 a.a.

Protein Preferred Names

Protein Names

integrator complex subunit 6

DEAD box protein

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06856	INTS6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INTS6	VGNC	VGNC:30232
Macaca mulatta	INTS6	VGNC	VGNC:103829
Canis familiaris	INTS6	VGNC	VGNC:42054
Felis catus	INTS6	VGNC	VGNC:97467
Rattus norvegicus	INTS6	RGD	RGD:1309480
Mus musculus	INTS6	MGD	MGI:1202397

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