VCX - variable charge X-linked Gene

Homo sapiens

Also known as VCX1; VCXB1; VCX-B1; VCX10R; VCX-10r

Gene ID: 26609 | Gene type: protein coding

About VCX

Cytogenetic location: Xp22.31 Genomic coordinates (GRCh38): X:7,842,262-7,844,143 (from NCBI)

This gene has 5 transcripts (splice variants), 34 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 23.7).

Summary

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]

VCX Products(2)

mRNA	Protein	Name
NM_001393662.1	NP_001380591.1	variable charge X-linked protein 1
NM_013452.3	NP_038480.2	variable charge X-linked protein 1

VCX Protein Structure

VCX_VCY

0
100
206 a.a.

Protein Preferred Names

Protein Names

variable charge X-linked protein 1

variable charge protein on X with ten repeats

Related Diseases

Diseases

Alias

Ichthyosis, X-Linked

X-Linked Ichthyosis	Steroid Sulfatase Deficiency
Placental Steroid Sulfatase Deficiency	Steroid Sulfatase Deficiency Disease
XLI	Sts Deficiency
Ssdd	X-Linked Recessive Ichthyosis
X-Linked Ichthyosis With Steryl-Sulphatase Deficiency	X-Linked Placental Steryl-Sulphatase Deficiency
Ssd	X Linked Ichthyosis
Recessive X-Linked Ichthyosis	Rxli
Syndromic Recessive X-Linked Ichthyosis	Recessive X-Linked Ichthyosis With Extracutaneous Manifestations
Syndromic Rxli	X-Linked Ichthyosis Syndrome
IXL	Ichthyosis X-Linked
Sex-Linked Ichthyosis	X-Linked Ichthyosis With Steryl-Sulfatase Deficiency

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Vertical Talus, Congenital

Congenital Vertical Talus	CVT
Congenital Convex Pes Valgus	Rocker-Bottom Foot Deformity
Vertical Talus	Pes Valgus, Congenital Convex
Congenital Convex Foot	Congenital Rocker-Bottom Foot
Rocker Bottom Foot	Flatfoot
Rocker-Bottom Foot	Charcot-Marie-Tooth Disease, Foot Deformity Of

Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis	Fhl
Familial Erythrophagocytic Lymphohistiocytosis	Hemophagocytic Syndrome
FHL1	Hplh1
Hlh1	Fel
Familial Hemophagocytic Lymphohistiocytosis 1	Primary Hemophagocytic Lymphohistiocytosis
Familial Hlh	Hlh
Familial Hemophagocytic Lymphocytosis	Hemophagocytic Lymphohistiocytosis, Familial
Reticulosis, Familial Histiocytic	Hemophagocytic Reticulosis, Familial
Erythrophagocytic Lymphohistiocytosis, Familial	Familial Histiocytic Reticulosis
Familial Hemophagocytic Histiocytosis	Familial Hemophagocytic Reticulosis
Fhlh	Hplh
Primary Hemophagocytic Hymphohistiocytosis	Genetic Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis	Familial Hemophagocytic Lymphohistiocytosis Type 1

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15625	VCX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15626	VCX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15627	VCX3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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