2. Gene
  3. NPAS4 - neuronal PAS domain protein 4 Gene

NPAS4 - neuronal PAS domain protein 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NXF; Le-PAS; PASD10; bHLHe79

Gene ID: 266743 | Gene type: protein coding

About NPAS4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,409,158-66,426,707 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 7 paralogues. Broad expression in brain (RPKM 1.7), endometrium (RPKM 1.7) and 14 other tissues.

Summary

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]

NPAS4 Products(2)

mRNA Protein Name
NM_001318804.1 NP_001305733.1 neuronal PAS domain-containing protein 4 isoform 2
NM_178864.4 NP_849195.2 neuronal PAS domain-containing protein 4 isoform 1

NPAS4 Protein Structure

PAS_3

PAS_3: PAS fold (229 - 296)

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  • 802 a.a.
Protein Preferred Names Protein Names

neuronal PAS domain-containing protein 4

HLH-PAS transcription factor NXF

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09471 NPAS4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NPAS4 MGD MGI:2664186
Macaca mulatta NPAS4 VGNC VGNC:75211
Rattus norvegicus NPAS4 RGD RGD:628866
Canis familiaris NPAS4 VGNC VGNC:43910
Bos taurus NPAS4 VGNC VGNC:32191
Felis catus NPAS4 VGNC VGNC:63865