2. Gene
  3. NDOR1 - NADPH dependent diflavin oxidoreductase 1 Gene

NDOR1 - NADPH dependent diflavin oxidoreductase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NR1; CIAE1; bA350O14.9

Gene ID: 27158 | Gene type: protein coding

About NDOR1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,205,700-137,219,361 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 6.1), bone marrow (RPKM 5.1) and 25 other tissues.

Summary

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

NDOR1 Products(4)

mRNA Protein Name
NM_001144026.3 NP_001137498.1 NADPH-dependent diflavin oxidoreductase 1 isoform a
NM_001144027.3 NP_001137499.1 NADPH-dependent diflavin oxidoreductase 1 isoform d
NM_001144028.3 NP_001137500.1 NADPH-dependent diflavin oxidoreductase 1 isoform c
NM_014434.4 NP_055249.1 NADPH-dependent diflavin oxidoreductase 1 isoform b

NDOR1 Protein Structure

Flavodoxin_1

Flavodoxin_1: Flavodoxin (8 - 145)

FAD_binding_1

FAD_binding_1: FAD binding domain (204 - 421)

NAD_binding_1

NAD_binding_1: Oxidoreductase NAD-binding domain (455 - 560)

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  • 597 a.a.
Protein Preferred Names Protein Names

NADPH-dependent diflavin oxidoreductase 1

NADPH-dependent FMN and FAD-containing oxidoreductase

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Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09112 NDOR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NDOR1 VGNC VGNC:75050
Bos taurus NDOR1 VGNC VGNC:31938
Rattus norvegicus NDOR1 RGD RGD:1308479
Mus musculus NDOR1 MGD MGI:1926047
Felis catus NDOR1 VGNC VGNC:63753
Canis familiaris NDOR1 VGNC VGNC:43677