2. Gene
  3. OXGR1 - oxoglutarate receptor 1 Gene

OXGR1 - oxoglutarate receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as aKGR; GPR80; GPR99; P2Y15; P2RY15

Gene ID: 27199 | Gene type: protein coding

About OXGR1

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:96,985,713-96,994,730 (from NCBI)

This gene has 4 transcripts (splice variants), 223 orthologues and 15 paralogues. Broad expression in kidney (RPKM 1.0), colon (RPKM 0.6) and 14 other tissues.

Summary

This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

OXGR1 Products(5)

mRNA Protein Name
NM_001346194.2 NP_001333123.1 2-oxoglutarate receptor 1
NM_001346195.2 NP_001333124.1 2-oxoglutarate receptor 1
NM_001346196.2 NP_001333125.1 2-oxoglutarate receptor 1
NM_001346197.2 NP_001333126.1 2-oxoglutarate receptor 1
NM_080818.5 NP_543008.3 2-oxoglutarate receptor 1

OXGR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 294)

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  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

2-oxoglutarate receptor 1

G protein-coupled receptor 80

Related Diseases

Diseases Alias
Tympanosclerosis

Ts - [Tympanosclerosis]

Tympanic Membrane Sclerosis
Tympanic Membrane Disease

Disorder Of Tympanic Membrane
Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09888 OXGR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus OXGR1 VGNC VGNC:67443
Bos taurus OXGR1 VGNC VGNC:32510
Macaca mulatta OXGR1 VGNC VGNC:75713
Mus musculus OXGR1 MGD MGI:2685145
Rattus norvegicus OXGR1 RGD RGD:1303155
Canis familiaris OXGR1 VGNC VGNC:57450