CHMP2A - charged multivesicular body protein 2A Gene

Homo sapiens

Also known as BC2; BC-2; VPS2; CHMP2; VPS2A

Gene ID: 27243 | Gene type: protein coding

About CHMP2A

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,551,566-58,555,105 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 34.2), kidney (RPKM 32.8) and 25 other tissues.

Summary

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP2A Products(2)

mRNA	Protein	Name
NM_014453.4	NP_055268.1	charged multivesicular body protein 2a
NM_198426.3	NP_940818.1	charged multivesicular body protein 2a

CHMP2A Protein Structure

Snf7

0
100
200
222 a.a.

Protein Preferred Names

Protein Names

charged multivesicular body protein 2a

VPS2 homolog A

Related Diseases

Diseases

Alias

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

Ftd3	Frontotemporal Dementia, Chromosome 3-Linked
Amyotrophic Lateral Sclerosis, Chmp2b-Related	Chromosome 3-Linked Frontotemporal Dementia
FTDALS7	Chmp2b-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 17, Formerly	Als17, Formerly
Amyotrophic Lateral Sclerosis Type 17	Dtm1
Ftd-3	Ftd-Chmp2b
Als17	Amyotrophic Lateral Sclerosis 17
Sclerosis, Lateral, Amyotrophic, Type 17	Dementia, Frontotemporal, Chromosome 3-Linked

Hypertrichosis Universalis Congenita, Ambras Type

Ambras Syndrome	Hypertrichosis, Congenital Generalized
HTC1	HTC2
Chromosome Xq27.1 Interchromosomal Insertion Syndrome	Cgh
Hcg	Ambras Type Hypertrichosis Universalis Congenita
X-Linked Congenital Generalized Hypertrichosis	Congenital Generalized Hypertrichosis, Macias-Flores Type
Macias Flores-Garcia Cruz-Rivera Syndrome	Htc 1
Hypertrichosis Universalis Congenita Ambras Type	Hypertrichosis Congenital Generalized X-Linked
Macias-Flores Garcia-Cruz Rivera Syndrome	Congenital Generalized Hypertrichosis, Ambras Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02640	CHMP2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHMP2A	MGD	MGI:1916203
Canis familiaris	CHMP2A	VGNC	VGNC:39222
Felis catus	CHMP2A	VGNC	VGNC:60862
Rattus norvegicus	CHMP2A	RGD	RGD:1305050
Bos taurus	CHMP2A	VGNC	VGNC:27300
Macaca mulatta	CHMP2A	VGNC	VGNC:71141

Name
Email *

	Sorry, but the email address you supplied was invalid.