2. Gene
  3. RNF115 - ring finger protein 115 Gene

RNF115 - ring finger protein 115 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BCA2; ZFP364; ZNF364; RABRING7

Gene ID: 27246 | Gene type: protein coding

About RNF115

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,738,868-145,824,095 (from NCBI)

This gene has 2 transcripts (splice variants), 256 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 16.1), fat (RPKM 8.2) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; protein autoubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RNF115 Products(1)

mRNA Protein Name
NM_014455.4 NP_055270.1 E3 ubiquitin-protein ligase RNF115

RNF115 Protein Structure

zinc_ribbon_9

zinc_ribbon_9: zinc-ribbon (19 - 48)

zf-RING_2

zf-RING_2: Ring finger domain (227 - 269)

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  • 304 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF115

RING-type E3 ubiquitin transferase RNF115

Related Diseases

Diseases Alias
Brachydactyly, Type A3

Brachydactyly Type A3

BDA3

Brachydactyly-Clinodactyly

Brachymesophalangy V

Brachymesophalangy 5

Brachydactyly Clinodactyly
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy

Hemiplegic Cerebral Palsy

Congenital Hemiplegia

Hemiplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Hemiplegic

Spastic Hemiplegia Cerebral Palsy

Hemiplegia, Spastic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12040 RNF115 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF115 RGD RGD:1305315
Canis familiaris RNF115 VGNC VGNC:45624
Macaca mulatta RNF115 VGNC VGNC:76762
Bos taurus RNF115 VGNC VGNC:34013
Mus musculus RNF115 MGD MGI:1915095
Felis catus RNF115 VGNC VGNC:80343