GLI4 - GLI family zinc finger 4 Gene

Homo sapiens

Also known as HKR4; ZNF928

Gene ID: 2738 | Gene type: protein coding

About GLI4

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,267,445-143,276,931 (from NCBI)

This gene has 11 transcripts (splice variants), 66 orthologues and 174 paralogues. Ubiquitous expression in fat (RPKM 5.3), spleen (RPKM 4.2) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GLI4 Products(1)

mRNA	Protein	Name
NM_138465.4	NP_612474.1	zinc finger protein GLI4

GLI4 Protein Structure

zf-H2C2_2

0
100
200
300
376 a.a.

Protein Preferred Names

Protein Names

zinc finger protein GLI4

GLI-Kruppel family member GLI4 (oncogene HKR4)

Related Diseases

Diseases

Alias

Parameningeal Embryonal Rhabdomyosarcoma

Heart Fibrosarcoma

Cardiac Fibrosarcoma

Fibrosarcoma Of The Heart

Joubert Syndrome 32

JBTS32

Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma	Anaplastic Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma, Adult Type

46,Xy Sex Reversal 7

SRXY7	46,Xy Sex Reversal, Partial Or Complete, Dhh-Related
46,Xy Gonadal Dysgenesis, Partial Or Complete, Dhh-Related	Gdxym
Gonadal Dysgenesis, Xy, Male-Limited	46xy Sex Reversal 7
Gonadal Dysgenesis, Xy, Male Limited	Complete Pure Gonadal Dysgenesis 46,Xy Type
Male-Limited Gonadal Dysgenesis 46,Xy	46,Xy Gonadal Dysgenesis, Complete Or Partial, Dhh-Related

Holoprosencephaly 9

Pituitary Anomalies With Holoprosencephaly-Like Features	HPE9
Holoprosencephaly With Microphthalmia And First Branchial Arch Anomalies	Holoprosencephaly-9
Holoprosencephaly, Type 9

Holoprosencephaly 7

HPE7	Holoprosencephaly-7
Holoprosencephaly, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05477	GLI4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GLI4	RGD	RGD:1560906
Canis familiaris	GLI4	VGNC	VGNC:41259

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