2. Gene
  3. MAT2B - methionine adenosyltransferase 2B Gene

MAT2B - methionine adenosyltransferase 2B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999

Gene ID: 27430 | Gene type: protein coding

About MAT2B

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:163,503,064-163,519,354 (from NCBI)

This gene has 33 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in lymph node (RPKM 45.7), thyroid (RPKM 43.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

MAT2B Products(2)

mRNA Protein Name
NM_013283.5 NP_037415.1 methionine adenosyltransferase 2 subunit beta isoform 1
NM_182796.2 NP_877725.1 methionine adenosyltransferase 2 subunit beta isoform 2

MAT2B Protein Structure

RmlD_sub_bind

RmlD_sub_bind: RmlD substrate binding domain (30 - 322)

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  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

methionine adenosyltransferase 2 subunit beta

MAT II beta

Related Diseases

Diseases Alias
Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Methionine Adenosyltransferase

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08168 MAT2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAT2B MGD MGI:1913667
Canis familiaris MAT2B VGNC VGNC:43038
Rattus norvegicus MAT2B RGD RGD:1593534
Felis catus MAT2B VGNC VGNC:102251
Macaca mulatta MAT2B VGNC VGNC:84437
Bos taurus MAT2B VGNC VGNC:31262