GLUD2 - glutamate dehydrogenase 2 Gene

Homo sapiens

Also known as GDH2; GLUDP1

Gene ID: 2747 | Gene type: protein coding

About GLUD2

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:121,047,610-121,050,094 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 285 orthologues, 1 paralogue and is associated with 1 phenotype.

Summary

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded Enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

GLUD2 Products(1)

mRNA	Protein	Name
NM_012084.4	NP_036216.2	glutamate dehydrogenase 2, mitochondrial precursor

GLUD2 Protein Structure

ELFV_dehydrog_N

ELFV_dehydrog

0
100
200
300
400
500
558 a.a.

Protein Preferred Names

Protein Names

glutamate dehydrogenase 2, mitochondrial

GDH 2

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hereditary Late-Onset Parkinson Disease

Autosomal Dominant Late-Onset Parkinson Disease	Lopd
Hereditary Late Onset Parkinson Disease

Depersonalization Disorder

Neurotic Derealization	Depersonalization
Depersonalization/Derealization Disorder	Depersonalisation-Derealization Syndrome
Depersonalisation Disorder	Depersonalisation Neurosis
Depersonalisation Syndrome	Feeling Of Unreality
Feels Own Self Is Unreal	Neurotic State With Depersonalisation
Neurotic State With Depersonalization Episode

Hyperinsulinemic Hypoglycemia, Familial, 6

Hyperinsulinism-Hyperammonemia Syndrome	HHF6
Familial Hyperinsulinemic Hypoglycemia 6	Hi/Ha Syndrome
Ha/Hi Syndrome	Hyperinsulinemic Hypoglycemia Familial 6
Hyperinsulinism Hyperammonemia Syndrome	Hhs

Spastic Paraplegia 34, X-Linked

SPG34	Hereditary Spastic Paraplegia 34
X-Linked Spastic Paraplegia Type 34	X-Linked Spastic Paraplegia 34

Glioblastoma Mesenchymal Subtype

Hypoglycemic Coma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05508	GLUD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GLUD2	MGD	MGI:95753

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