GOLGA4 - golgin A4 Gene

Homo sapiens

Also known as GCP2; GOLG; p230; CRPF46; MU-RMS-40.18

Gene ID: 2803 | Gene type: protein coding

About GOLGA4

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,243,271-37,366,879 (from NCBI)

This gene has 14 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues.

Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GOLGA4 Products(3)

mRNA	Protein	Name
NM_001172713.2	NP_001166184.1	golgin subfamily A member 4 isoform 1
NM_001410721.1	NP_001397650.1	golgin subfamily A member 4 isoform 3
NM_002078.5	NP_002069.2	golgin subfamily A member 4 isoform 2

GOLGA4 Protein Structure

GRIP

0
400
800
1200
1600
2000
2230 a.a.

Protein Preferred Names

Protein Names

golgin subfamily A member 4

256 kDa golgin

Related Diseases

Diseases

Alias

Chronic Neutrophilic Leukemia

Cnl	Leukemia Neutrophilic Chronic

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Alzheimer Disease 14

AD14	Alzheimer'S Disease 14
Alzheimer Disease-14	Alzheimer'S Disease 14, Late Onset

Glycogen Storage Disease Ixa

Glycogen Storage Disease Type 9a	Glycogen Storage Disease Type Ixa
Glycogenosis Type 9a	Glycogenosis Type Ixa
Gsd Type 9a	Gsd Type Ixa
Gsd9a

Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2	Pontocerebellar Hypoplasia Type 2e
Pch2	PCH2E
Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy	Pontocerebellar Hypoplasia 2e
Pcca2	Progressive Cerebello-Cerebral Atrophy Type 2
Doid:0112328	Hypoplasia, Pontocerebellar, Type 2e
Pontocerebellar Hypoplasia, Type 2d	Pontocerebellar Hypoplasia Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05585	GOLGA4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GOLGA4	MGD	MGI:1859646
Bos taurus	GOLGA4	VGNC	VGNC:29485
Rattus norvegicus	GOLGA4	RGD	RGD:1591925
Canis familiaris	GOLGA4	VGNC	VGNC:41340
Felis catus	GOLGA4	VGNC	VGNC:62639
Macaca mulatta	GOLGA4	VGNC	VGNC:73107

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