GPI - glucose-6-phosphate isomerase Gene

Homo sapiens

Also known as AMF; NLK; PGI; PHI; GNPI; SA36; SA-36

Gene ID: 2821 | Gene type: protein coding

About GPI

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:34,359,718-34,402,413 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 278 orthologues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 54.9), fat (RPKM 52.6) and 25 other tissues.

Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic Enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe Enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GPI Products(7)

mRNA	Protein	Name
NM_000175.5	NP_000166.2	glucose-6-phosphate isomerase isoform 2
NM_001184722.1	NP_001171651.1	glucose-6-phosphate isomerase isoform 1
NM_001289789.1	NP_001276718.1	glucose-6-phosphate isomerase isoform 3
NM_001289790.3	NP_001276719.1	glucose-6-phosphate isomerase isoform 4
NM_001329909.1	NP_001316838.1	glucose-6-phosphate isomerase isoform 2
NM_001329910.1	NP_001316839.1	glucose-6-phosphate isomerase isoform 2
NM_001329911.2	NP_001316840.1	glucose-6-phosphate isomerase isoform 5

GPI Protein Structure

PGI

0
100
200
300
400
500
558 a.a.

Protein Preferred Names

Protein Names

glucose-6-phosphate isomerase

autocrine motility factor

Recombinant GPI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71680	Glucose-6-phosphate isomerase Protein, Human (His)	P06744 (A2-E554)	≥95%

Related Diseases

Diseases

Alias

Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency

Hemolytic Anemia Due To Glucophosphate Isomerase Deficiency	Hemolytic Anemia, Non-Spherocytic, Due To Glucose Phosphate Isomerase Deficiency
HA-GPID	Anemia, Hemolytic, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Congenital Nonspherocytic Hemolytic Anemia

Hereditary Non-Spherocytic Hemolytic Anemia	Hereditary Nonspherocytic Hemolytic Anemia
Anemia, Hemolytic, Congenital Nonspherocytic	Congenital Nonspherocytic Hemolytic Anaemia
Hereditary Nonspherocytic Hemolytic Anaemia	Hnsha

Cutaneous Leishmaniasis

Diffuse Cutaneous Leishmaniasis	Asian Desert Cutaneous Leishmaniasis
Leishmaniasis, Cutaneous	Leproid Leishmaniasis
Leishmaniasis Diffuse Cutaneous	Leishmaniasis Cutaneous
Ethiopian Cutaneous Leishmaniasis	Old World Cutaneous Leishmaniasis

Congenital Hemolytic Anemia

Anemia Hemolytic Congenital	Anemia, Hemolytic, Congenital
Congenital Hemolytic Anaemia	Hereditary Hemolytic Anaemia
Hereditary Hemolytic Anemia

Transient Arthritis

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Hyperoxaluria, Primary, Type Iii

Primary Hyperoxaluria Type 3	HP3
Ph Iii	Primary Hyperoxaluria Type Iii
Hyperoxaluria Primary 3	Hyperoxaluria Non-Hp1/Non-Hp2
Hyperoxaluria Non-Ph I/Ph Ii Form	Hyperoxaluria Primary Type Iii

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Triosephosphate Isomerase Deficiency

TPID	Triose Phosphate-Isomerase Deficiency
Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency	Tpi Deficiency
Triose Phosphate Isomerase Deficiency	Deficiency Of Phosphotriose Isomerase
Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Hereditary Spherocytosis

Congenital Spherocytic Hemolytic Anemia	Spherocytic Anemia
Congenital Spherocytosis	Spherocytosis, Type 1
Minkowski Chauffard Syndrome	Hs
Minkowski-Chauffard Disease	Minkowski-Chauffard Syndrome
Spherocytosis Hereditary	Spherocytosis, Hereditary
Anemia, Hereditary Spherocytic Hemolytic

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2918	Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae)		/	Phase 4
HY-18233	Manogepix	Inhibitor	99.85%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99006	Amatuximab	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108615	CP-316819	Inhibitor	≥99.0%	Unkown
HY-124619	GPI-1046	Inhibitor	99.74%	Unkown
HY-129035	PFI-653	Inhibitor	99.88%	Unkown
HY-136424	GPI-1485		99.88%	Yes
HY-19396	Ingliforib	Inhibitor	99.64%	Unkown
HY-103345	2-MPPA	Inhibitor	≥98.0%	Unkown
HY-147110	APX2039	Inhibitor	98.12%	Unkown
HY-131455A	Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA		≥98.0%	Unkown
HY-13540	E7016	Inhibitor	98.46%	Unkown
HY-P1596	Gluten Exorphin C	Inhibitor	98.97%	Unkown
HY-108614	GPi688	Inhibitor	/	Unkown
HY-145316	Vanin-1-IN-2	Inhibitor	/	Unkown
HY-P3632	[DAla2, DArg6] Dynorphin A, (1-13) (porcine)		/	Unkown
HY-RS05639	GPI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPI	VGNC	VGNC:41381
Felis catus	GPI	VGNC	VGNC:67409
Bos taurus	GPI	VGNC	VGNC:29534
Rattus norvegicus	GPI	RGD	RGD:2727
Mus musculus	GPI	MGD	MGI:95797
Macaca fascicularis	GPI	NCBI
Macaca mulatta	GPI	NCBI
Others	GPI	NCBI

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