GPR3 - G protein-coupled receptor 3 Gene

Homo sapiens

Also known as ACCA

Gene ID: 2827 | Gene type: protein coding

About GPR3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,392,622-27,395,814 (from NCBI)

This gene has 1 transcript (splice variant), 183 orthologues and 18 paralogues. Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues.

Summary

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates Adenylate Cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

GPR3 Products(1)

mRNA	Protein	Name
NM_005281.4	NP_005272.1	G-protein coupled receptor 3

GPR3 Protein Structure

7tm_1

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 3

ACCA orphan receptor

Related Diseases

Diseases

Alias

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108496	Sphingosine-1-phosphate	Agonist	≥98.0%	Unkown
HY-12664	AF64394	Antagonist	98.01%	Unkown
HY-108496S	Sphingosine-1-phosphate-d7	Agonist	≥99.0%	Unkown
HY-155318A	GPR3 agonist-2	Agonist	98.80%	Unkown
HY-RS05700	GPR3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPR3	RGD	RGD:628686
Mus musculus	GPR3	MGD	MGI:101908
Bos taurus	GPR3	VGNC	VGNC:29581
Canis familiaris	GPR3	VGNC	VGNC:41429
Macaca mulatta	GPR3	VGNC	VGNC:73131
Felis catus	GPR3	VGNC	VGNC:67423
Others	GPR3	NCBI

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