CDH20 - cadherin 20 Gene

Homo sapiens

Also known as Cdh7; CDH7L3

Gene ID: 28316 | Gene type: protein coding

About CDH20

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:61,333,430-61,555,779 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues and 33 paralogues. Biased expression in brain (RPKM 10.7) and fat (RPKM 4.1).

Summary

This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, Cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]

CDH20 Products(1)

mRNA	Protein	Name
NM_031891.4	NP_114097.2	cadherin-20 preproprotein

CDH20 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
801 a.a.

Protein Preferred Names

Protein Names

cadherin-20

cadherin 20, type 2

Recombinant CDH20 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79190	Cadherin-20 Protein, Human (CHO, His)	Q9HBT6 (D35-R619)	≥95%

Related Diseases

Diseases

Alias

Craniofacial-Deafness-Hand Syndrome

CDHS	Craniofacial Deafness Hand Syndrome
Sommer-Young-Wee-Frye Syndrome	Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss
Craniofacial-Hearing Loss-Hand Syndrome

Choanal Atresia, Posterior

Choanal Atresia	Atresia Of Nares
Posterior Choanal Atresia	PCA
Imperforate Nares	Choanal Fusion
Congenital Stenosis Of Nares	Congenital Stenosis Of Choanae
Nasal Atresia Nos

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02331	CDH20 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDH20	VGNC	VGNC:39029
Rattus norvegicus	CDH20	RGD	RGD:1305438
Bos taurus	CDH20	VGNC	VGNC:27099
Felis catus	CDH20	VGNC	VGNC:60679
Macaca mulatta	CDH20	VGNC	VGNC:70970
Mus musculus	CDH20	MGD	MGI:1346069

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