SLC39A5 - solute carrier family 39 member 5 Gene

Homo sapiens

Also known as ZIP5; MYP24; LZT-Hs7

Gene ID: 283375 | Gene type: protein coding

About SLC39A5

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,230,051-56,237,846 (from NCBI)

This gene has 11 transcripts (splice variants), 161 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 78.5), small intestine (RPKM 76.3) and 4 other tissues.

Summary

The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

SLC39A5 Products(2)

mRNA	Protein	Name
NM_001135195.1	NP_001128667.1	zinc transporter ZIP5 precursor
NM_173596.3	NP_775867.2	zinc transporter ZIP5 precursor

SLC39A5 Protein Structure

Zip

0
100
200
300
400
500
540 a.a.

Protein Preferred Names

Protein Names

zinc transporter ZIP5

ZRT/IRT-like protein 5

Related Diseases

Diseases

Alias

Myopia 24, Autosomal Dominant

MYP24

Myopia, Type 24, Autosomal Dominant

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Refractive Error

Refractive Errors

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica	AEZ
Enteropathica	Brandt Syndrome
Ae	Acrodermatitis Enteropathica Zinc Deficiency Type
Danbolt-Cross Syndrome	Acrodermatitis Enteropathica, Zinc Deficiency Type
Inherited Zinc Deficiency	Acrodermatitis Enteropathica, Zinc Deficiency
Danbolt-Closs Syndrome	Primary Zinc Malabsorption Syndrome

Hypermanganesemia With Dystonia 2

HMNDYT2	Dystonia-Parkinsonism-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia, Type 2

Hypermanganesemia With Dystonia 1

Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis	HMNDYT1
Hmdpc	Hypermanganesemia With Dystonia Polycythemia And Cirrhosis
Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease	Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome

Hypermanganesemia With Dystonia

Familial Manganese-Induced Neurotoxicity

Hmndyt

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13236	SLC39A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC39A5	VGNC	VGNC:82239
Mus musculus	SLC39A5	MGD	MGI:1919336
Felis catus	SLC39A5	VGNC	VGNC:65361
Bos taurus	SLC39A5	VGNC	VGNC:34865
Rattus norvegicus	SLC39A5	RGD	RGD:1310322

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