MCHR1 - melanin concentrating hormone receptor 1 Gene

Homo sapiens

Also known as SLC1; GPR24; MCH1R; SLC-1; MCH-1R

Gene ID: 2847 | Gene type: protein coding

About MCHR1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:40,679,484-40,682,812 (from NCBI)

This gene has 4 transcripts (splice variants), 241 orthologues and 33 paralogues. Biased expression in brain (RPKM 4.7), ovary (RPKM 1.2) and 5 other tissues.

Summary

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

MCHR1 Products(1)

mRNA	Protein	Name
NM_005297.4	NP_005288.4	melanin-concentrating hormone receptor 1

MCHR1 Protein Structure

7tm_1

0
100
200
300
422 a.a.

Protein Preferred Names

Protein Names

melanin-concentrating hormone receptor 1

G protein-coupled receptor 24	MCH receptor 1
somatostatin receptor-like protein

Related Diseases

Diseases

Alias

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Meckel Syndrome, Type 1

Meckel Syndrome	Meckel-Gruber Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo	VAMAS1
Slev1	Vtlg
Systemic Lupus Erythematosus, Vitiligo-Related	Vitiligo-Associated Multiple Autoimmune Disease 1
Systemic Lupus Erythematosus Vitiligo-Related

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Iminoglycinuria

Iminoglycinuria, Digenic

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00257	AZD1979	Antagonist	98.09%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107625A	SNAP 94847 hydrochloride	Inhibitor	99.90%	Unkown
HY-P1204	[Ala17]-MCH	Agonist	98.28%	Unkown
HY-100321	MCHR1 antagonist 2		98.27%	Unkown
HY-12433	BMS-819881		/	Unkown
HY-100318	NGD-4715	Antagonist	/	Unkown
HY-107625	SNAP 94847	Antagonist	/	Unkown
HY-120608	BMS-814580	Inhibitor	/	Unkown
HY-136152	MCHR1 antagonist 3	Antagonist	/	Unkown
HY-P1204A	[Ala17]-MCH TFA	Agonist	/	Unkown
HY-RS08225	MCHR1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08226	Mchr1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08227	Mchr1 Rat Pre-designed siRNA Set A		/	Unkown
HY-101699A	AMG-076	Antagonist	/	Unkown
HY-U00353	MCHR1 antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MCHR1	VGNC	VGNC:95360
Mus musculus	MCHR1	MGD	MGI:2180756
Felis catus	MCHR1	VGNC	VGNC:67422
Rattus norvegicus	MCHR1	RGD	RGD:619841
Canis familiaris	MCHR1	VGNC	VGNC:43076
Bos taurus	MCHR1	VGNC	VGNC:31305

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