SCAI - suppressor of cancer cell invasion Gene

Homo sapiens

Also known as NET40; C9orf126

Gene ID: 286205 | Gene type: protein coding

About SCAI

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,942,608-125,143,528 (from NCBI)

This gene has 7 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in brain (RPKM 4.6), lung (RPKM 2.0) and 24 other tissues.

Summary

This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (Ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

SCAI Products(2)

mRNA	Protein	Name
NM_001144877.3	NP_001138349.1	protein SCAI isoform 2
NM_173690.5	NP_775961.2	protein SCAI isoform 1

SCAI Protein Structure

SCAI

0
100
200
300
400
500
606 a.a.

Protein Preferred Names

Protein Names

protein SCAI

suppressor of cancer cell invasion protein

Related Diseases

Diseases

Alias

Vertebral Artery Insufficiency

Vertebral Artery Syndrome

Lateral Myocardial Infarction

Spinocerebellar Ataxia, X-Linked 2

Scax2	X-Linked Spinocerebellar Ataxia 2
Cerebellar Ataxia With Extrapyramidal Involvement Early-Onset	Cerebellar Ataxia With Extrapyramidal Involvement, Early-Onset
Spinocerebellar Ataxia X-Linked Type 2

Subclavian Steal Syndrome

Subclavian Artery Stenosis	Subclavian Steal Phenomenon
Subclavian Steal Steno-Occlusive Disease	Subclavian Steal

Thrombophilia, X-Linked, Due To Factor Ix Defect

THPH8	Deep Venous Thrombosis, Protection Against
X-Linked Thrombophilia Due To Factor Ix Defect	Thrombophilia, X-Linked, Due To Factor 9 Defect
Thrombophilia 8, X-Linked, Due To Factor Ix Defect

Hyperinsulinemic Hypoglycemia, Familial, 4

Hyperinsulinism Due To Glutamodehydrogenase Deficiency	HHF4
Familial Hyperinsulinemic Hypoglycemia 4	Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Hyperinsulinism Due To Schad Deficiency	Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Congenital Hyperinsulinism	Schad Deficiency
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Left Bundle Branch Hemiblock

Left Bundle Branch Block

Left Bundle-Branch Block

Aortic Valve Insufficiency

Aortic Regurgitation	Rheumatic Aortic Regurgitation
Aortic Insufficiency	Rheumatic Aortic Insufficiency
Rheumatic Aortic Valve Insufficiency	Aortic Incompetence
Corrigan'S Disease	Rheumatic Aortic Valve Regurgitation
Aortic Valve Incompetency	Ai - [Aortic Incompetence]
Incompetent Aortic Valve	Ar - [Aortic Regurgitation]
Calcific Aortic Valve Regurgitation	Myxomatous Aortic Valve Regurgitation
Annular Incompetency Of Aortic Valve	Austin Flint Murmur
Flint Murmur	Rheumatic Aortic Incompetence
Rheumatic Ai - [Aortic Insufficiency]

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12477	SCAI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCAI	RGD	RGD:1594720
Felis catus	SCAI	VGNC	VGNC:102978
Mus musculus	SCAI	MGD	MGI:2443716

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