2. Gene
  3. GPS2 - G protein pathway suppressor 2 Gene

GPS2 - G protein pathway suppressor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AMF-1

Gene ID: 2874 | Gene type: protein coding

About GPS2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,312,661-7,315,360 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele and 222 orthologues. Ubiquitous expression in testis (RPKM 54.8), spleen (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

GPS2 Products(1)

mRNA Protein Name
NM_004489.5 NP_004480.1 G protein pathway suppressor 2
Protein Preferred Names Protein Names

G protein pathway suppressor 2

GPS-2

Related Diseases

Diseases Alias
Liposarcoma

Lipomatous Cancer
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05758 GPS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPS2 MGD MGI:1891751
Felis catus GPS2 VGNC VGNC:99074
Canis familiaris GPS2 VGNC VGNC:41456
Macaca mulatta GPS2 VGNC VGNC:99156
Rattus norvegicus GPS2 RGD RGD:1562746
Bos taurus GPS2 VGNC VGNC:29613