2. Gene
  3. GRIK3 - glutamate ionotropic receptor kainate type subunit 3 Gene

GRIK3 - glutamate ionotropic receptor kainate type subunit 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EAA5; GLR7; GLUR7; GluK3; GluR7a

Gene ID: 2899 | Gene type: protein coding

About GRIK3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,795,527-37,034,515 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 17 paralogues. Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues.

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

GRIK3 Products(1)

mRNA Protein Name
NM_000831.4 NP_000822.2 glutamate receptor ionotropic, kainate 3 precursor

GRIK3 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (57 - 396)

Lig_chan-Glu_bd

Lig_chan-Glu_bd: Ligated ion channel L-glutamate- and glycine-binding site (445 - 509)

Lig_chan

Lig_chan: Ligand-gated ion channel (563 - 832)

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  • 919 a.a.
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 3

dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))

Related Diseases

Diseases Alias
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Depersonalization Disorder

Neurotic Derealization

Depersonalization

Depersonalization/Derealization Disorder

Depersonalisation-Derealization Syndrome

Depersonalisation Disorder

Depersonalisation Neurosis

Depersonalisation Syndrome

Feeling Of Unreality

Feels Own Self Is Unreal

Neurotic State With Depersonalisation

Neurotic State With Depersonalization Episode
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior
Neuronitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05800 GRIK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GRIK3 VGNC VGNC:41488
Macaca mulatta GRIK3 VGNC VGNC:73278
Bos taurus GRIK3 VGNC VGNC:29644
Mus musculus GRIK3 MGD MGI:95816
Felis catus GRIK3 VGNC VGNC:67469
Rattus norvegicus GRIK3 RGD RGD:71027