GRIK4 - glutamate ionotropic receptor kainate type subunit 4 Gene

Homo sapiens

Also known as KA1; EAA1; GRIK; GluK4; GluK4-2

Gene ID: 2900 | Gene type: protein coding

About GRIK4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:120,511,748-120,988,906 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues and 17 paralogues. Biased expression in brain (RPKM 2.8), ovary (RPKM 0.9) and 4 other tissues.

Summary

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GRIK4 Products(3)

mRNA	Protein	Name
NM_001282470.3	NP_001269399.1	glutamate receptor ionotropic, kainate 4 isoform 1 precursor
NM_001282473.3	NP_001269402.1	glutamate receptor ionotropic, kainate 4 isoform 2 precursor
NM_014619.5	NP_055434.2	glutamate receptor ionotropic, kainate 4 isoform 1 precursor

GRIK4 Protein Structure

ANF_receptor

Lig_chan-Glu_bd

Lig_chan

0
200
400
600
800
956 a.a.

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, kainate 4

GluK4(alt_5'UTR)

Related Diseases

Diseases

Alias

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation

Depersonalization Disorder

Neurotic Derealization	Depersonalization
Depersonalization/Derealization Disorder	Depersonalisation-Derealization Syndrome
Depersonalisation Disorder	Depersonalisation Neurosis
Depersonalisation Syndrome	Feeling Of Unreality
Feels Own Self Is Unreal	Neurotic State With Depersonalisation
Neurotic State With Depersonalization Episode

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

MLC2A	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a
Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05801	GRIK4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GRIK4	MGD	MGI:95817
Felis catus	GRIK4	VGNC	VGNC:103032
Macaca mulatta	GRIK4	VGNC	VGNC:73279
Rattus norvegicus	GRIK4	RGD	RGD:2734
Canis familiaris	GRIK4	VGNC	VGNC:41489
Bos taurus	GRIK4	VGNC	VGNC:54882

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