GRM4 - glutamate metabotropic receptor 4 Gene

Homo sapiens

Also known as mGlu4; GPRC1D; MGLUR4

Gene ID: 2914 | Gene type: protein coding

About GRM4

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,018,643-34,155,622 (from NCBI)

This gene has 14 transcripts (splice variants), 271 orthologues and 7 paralogues. Low expression observed in reference dataset.

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GRM4 Products(8)

mRNA	Protein	Name
NM_001256810.1
NM_001256814.1
NM_001256811.3	NP_001243740.1	metabotropic glutamate receptor 4 isoform 4 precursor
NM_001256813.3	NP_001243742.1	metabotropic glutamate receptor 4 isoform 6
NM_001256812.2	NP_001243741.1	metabotropic glutamate receptor 4 isoform 5
NM_001282847.2	NP_001269776.1	metabotropic glutamate receptor 4 isoform 8
NM_000841.4	NP_000832.1	metabotropic glutamate receptor 4 isoform 1 precursor
NM_001256809.3	NP_001243738.1	metabotropic glutamate receptor 4 isoform 2

GRM4 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
912 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 4

glutamate receptor, metabotropic 4

Related Diseases

Diseases

Alias

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy	Janz Syndrome
Jme	Myoclonic Epilepsy, Juvenile, Susceptibility To, 1
EJM	Myoclonic Epilepsy, Juvenile
Petit Mal, Impulsive	Myoclonic Epilepsy, Juvenile 1
Myoclonic Epilepsy, Juvenile, 1	Adolescent Myoclonic Epilepsy
Juvenile Myoclonus Epilepsy	Juvenile Myoclonic Epilepsy 1
EJM1	Petit Mal Impulsive
Susceptibility To Juvenile Myoclonic Epilepsy 1	Myoclonic Epilepsy Juvenile
Epilepsy, Myoclonic, Juvenile	Myoclonic Epilepsy Of Janz
Jme - [Juvenile Myoclonic Epilepsy]

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05828	GRM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05829	Grm4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05830	Grm4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GRM4	VGNC	VGNC:67479
Mus musculus	GRM4	MGD	MGI:1351341
Macaca mulatta	GRM4	VGNC	VGNC:73288
Rattus norvegicus	GRM4	RGD	RGD:2745
Bos taurus	GRM4	VGNC	VGNC:53975
Canis familiaris	GRM4	VGNC	VGNC:41511

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