GRM7 - glutamate metabotropic receptor 7 Gene

Homo sapiens

Also known as GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87

Gene ID: 2917 | Gene type: protein coding

About GRM7

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:6,861,115-7,741,533 (from NCBI)

This gene has 15 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

GRM7 Products(8)

mRNA	Protein	Name
NM_000844.4	NP_000835.1	metabotropic glutamate receptor 7 isoform a precursor
XM_017006273.2	XP_016861762.1	metabotropic glutamate receptor 7 isoform X4
XM_047448053.1	XP_047304009.1	metabotropic glutamate receptor 7 isoform X2
XM_017006272.2	XP_016861761.1	metabotropic glutamate receptor 7 isoform X3
XR_001740135.3
XM_047448052.1	XP_047304008.1	metabotropic glutamate receptor 7 isoform X1
NM_181875.1
NM_181874.3	NP_870989.1	metabotropic glutamate receptor 7 isoform b precursor

GRM7 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
915 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 7

glutamate receptor, metabotropic 7

protein phosphatase 1, regulatory subunit 87

Recombinant GRM7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79400	mGluR7 Protein, Human (CHO, His)	Q14831-1 (Q35-S521)	≥95%

Related Diseases

Diseases

Alias

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type

Mecp2 Duplication Syndrome	Lubs X-Linked Mental Retardation Syndrome
MRXSL	Trisomy Xq28
Mental Retardation, X-Linked, With Recurrent Respiratory Infections	Intellectual Developmental Disorder, X-Linked Syndromic, Lubs Type
Mental Retardation, X-Linked, Lubs Type	Xlmr Syndrome, Lubs Type

Gene Duplication Disease

Gene Duplication Syndrome

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities

NEDSHBA

Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Abnormalities

Deafness, Autosomal Dominant 28

DFNA28	Autosomal Dominant Nonsyndromic Deafness 28
Autosomal Dominant Deafness 28	Deafness, Autosomal Dominant, 28
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28
Deafness, Autosomal Dominant, Type 28

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Suppression Bursts	Early Infantile Epileptic Encephalopathy With Burst-Suppression
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Amyotrophic Lateral Sclerosis 19

Amyotrophic Lateral Sclerosis Type 19	ALS19
Sclerosis, Lateral, Amyotrophic, Type 19

Hypotonia

Cerebral Atrophy

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Deafness, Autosomal Dominant 64

DFNA64	Autosomal Dominant Nonsyndromic Deafness 64
Autosomal Dominant Deafness 64	Deafness, Autosomal Dominant, 64
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64
Deafness, Autosomal Dominant, Type 64

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS05837	GRM7 Human Pre-designed siRNA Set A	/	Unkown
HY-RS05838	Grm7 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS05839	Grm7 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GRM7	MGD	MGI:1351344
Bos taurus	GRM7	VGNC	VGNC:29662
Macaca mulatta	GRM7	VGNC	VGNC:73291
Canis familiaris	GRM7	VGNC	VGNC:41514
Rattus norvegicus	GRM7	RGD	RGD:619857
Felis catus	GRM7	VGNC	VGNC:102595

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