Map4k1 - mitogen activated protein kinase kinase kinase kinase 1 Gene

Rattus norvegicus

Also known as Hpk1

Gene ID: 292763 | Gene type: protein coding

About Map4k1

Primary_assembly 1: 84,271,069-84,292,493 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 197 orthologues, 36 paralogues and is associated with 1 phenotype. Biased expression in Spleen (RPKM 137.9), Thymus (RPKM 92.1) and 4 other tissues.

Summary

Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Used to study transient cerebral ischemia. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map4k1 Products(1)

mRNA	Protein	Name
NM_001106243.1	NP_001099713.1	mitogen-activated protein kinase kinase kinase kinase 1

Map4k1 Protein Structure

STKc_MAP4K3_like

CNH

0
200
400
600
827 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

hematopoietic progenitor kinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138568	HPK1-IN-3	Inhibitor	99.32%	Unkown
HY-138742	HPK1-IN-7	Inhibitor	99.33%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-143868	HPK1-IN-27	Inhibitor	/	Unkown
HY-143871	HPK1-IN-30	Inhibitor	/	Unkown
HY-156509	HPK1-IN-38	Inhibitor	/	Unkown
HY-RS08071	MAP4K1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08072	Map4k1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08073	Map4k1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map4k1	NCBI	NCBI:11184

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