2. Gene
  3. GSPT1 - G1 to S phase transition 1 Gene

GSPT1 - G1 to S phase transition 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GST1; ETF3A; eRF3a; 551G9.2

Gene ID: 2935 | Gene type: protein coding

About GSPT1

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,868,128-11,916,654 (from NCBI)

This gene has 10 transcripts (splice variants), 283 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 16.3), colon (RPKM 15.7) and 25 other tissues.

Summary

Enables translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. [provided by Alliance of Genome Resources, Apr 2022]

GSPT1 Products(3)

mRNA Protein Name
NM_001130006.2 NP_001123478.2 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2
NM_001130007.2 NP_001123479.1 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3
NM_002094.4 NP_002085.3 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

GSPT1 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (72 - 271)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (314 - 381)

GTP_EFTU_D3

GTP_EFTU_D3: Elongation factor Tu C-terminal domain (391 - 494)

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  • 499 a.a.
Protein Preferred Names Protein Names

eukaryotic peptide chain release factor GTP-binding subunit ERF3A

G1 to S phase transition protein 1 homolog

Related Diseases

Diseases Alias
Duane-Radial Ray Syndrome

Okihiro Syndrome

DRRS

Dr Syndrome

Duane Anomaly With Radial Ray Abnormalities And Deafness

Acrorenoocular Syndrome

Acrorenocular Syndrome

Duane Anomaly With Radial Abnormalities And Deafness

Acro-Renal-Ocular Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-130800 Eragidomide 99.86% Phase 2
HY-153356 MRT-2359 Inducer 99.98% Phase 2
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101488 CC-885 99.85% Unkown
HY-132199 SJ6986 Inhibitor 98.00% Unkown
HY-147158 ZXH-1-161 Modulator 98.92% Unkown
HY-130122 MG-277 Inducer 98.66% Unkown
HY-151902 SJ988497 98.05% Unkown
HY-136688 MI-389 99.34% Unkown
HY-150616 SJPYT-195 99.41% Unkown
HY-153803 GBD-9 Inhibitor 99.76% Unkown
HY-143435 AG6033 Inducer / Unkown
HY-148837 c-Myc inhibitor 7 / Unkown
HY-150259 MDEG-541 Degrader / Unkown
HY-155552 GSPT1 degrader-1 / Unkown
HY-156747 GSPT1 degrader-2 / Unkown
HY-157426 GSPT1 degrader-3 Degrader / Unkown
HY-RS05868 GSPT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GSPT1 MGD MGI:1316728
Canis familiaris GSPT1 VGNC VGNC:41533
Felis catus GSPT1 VGNC VGNC:67487
Rattus norvegicus GSPT1 RGD RGD:2751
Macaca mulatta GSPT1 VGNC VGNC:73300
Bos taurus GSPT1 VGNC VGNC:29681