2. Gene
  3. Aldh2 - aldehyde dehydrogenase 2 family member Gene

Aldh2 - aldehyde dehydrogenase 2 family member Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29539 | Gene type: protein coding

About Aldh2

Primary_assembly 12: 34,901,219-34,982,521 forward strand.mRatBN7.2:CM026985.1

This gene has 7 transcripts (splice variants), 224 orthologues and 20 paralogues. Biased expression in Liver (RPKM 1581.), Adrenal (RPKM 143.4) and 9 other tissues.

Summary

Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Aldh2 Products(1)

mRNA Protein Name
NM_032416.2 NP_115792.2 aldehyde dehydrogenase, mitochondrial precursor

Aldh2 Protein Structure

ALDH_F1AB_F2_RALDH1

ALDH_F1AB_F2_RALDH1: cd07141 (32 - 512)

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  • 519 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase, mitochondrial

ALDH class 2

ALDH-E2

ALDH1

aldehyde dehydrogenase 2 family (mitochondrial)

aldehyde dehydrogenase 2, mitochondrial

mitochondrial aldehyde dehydrogenase

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride Inhibitor 99.86% Unkown
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113466 4-Hydroxynonenal Inhibitor ≥99.0% Unkown
HY-18936 Alda-1 Agonist 99.99% Unkown
HY-19801 CVT-10216 Inhibitor ≥99.0% Unkown
HY-146683 KS106 Inhibitor 99.31% Unkown
HY-76006 3-Hydroxybenzaldehyde 99.85% Unkown
HY-113466S 4-Hydroxynonenal-d3 Inhibitor ≥99.0% Unkown
HY-126241 RV01 Inhibitor 98.0% Unkown
HY-148617 ALDH2 modulator 1 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh2 NCBI NCBI:217