SNX10 - sorting nexin 10 Gene

Homo sapiens

Also known as OPTB8

Gene ID: 29887 | Gene type: protein coding

About SNX10

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,291,862-26,374,383 (from NCBI)

This gene has 27 transcripts (splice variants), 278 orthologues, 15 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 20.5), appendix (RPKM 13.4) and 19 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

SNX10 Products(8)

mRNA	Protein	Name
NM_001199835.1	NP_001186764.1	sorting nexin-10 isoform 1
NM_001199837.3	NP_001186766.1	sorting nexin-10 isoform 2
NM_001199838.2	NP_001186767.1	sorting nexin-10 isoform 3
NM_001318198.1	NP_001305127.1	sorting nexin-10 isoform 4
NM_001318199.3	NP_001305128.1	sorting nexin-10 isoform 1
NM_001362753.1	NP_001349682.1	sorting nexin-10 isoform 4
NM_001362754.1	NP_001349683.1	sorting nexin-10 isoform 4
NM_013322.3	NP_037454.2	sorting nexin-10 isoform 1

SNX10 Protein Structure

0
100
201 a.a.

Protein Preferred Names

Protein Names

sorting nexin-10

Related Diseases

Diseases

Alias

Osteopetrosis, Autosomal Recessive 8

Autosomal Recessive Osteopetrosis 8	OPTB8
Osteopetrosis, Autosomal Recessive, Type 8

Autosomal Recessive Malignant Osteopetrosis

Infantile Malignant Osteopetrosis

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Osteopetrosis, Autosomal Recessive 2

OPTB2	Autosomal Recessive Osteopetrosis 2
Osteopetrosis, Mild Autosomal Recessive Form	Osteoclast-Poor Osteopetrosis
Osteopetrosis, Osteoclast-Poor	Mild Autosomal Recessive Form Osteopetrosis
Osteopetrosis Autosomal Recessive 2	Autosomal Recessive Osteopetrosis Type 2
Osteopetrosis Osteoclast-Poor	Osteopetrosis, Autosomal Recessive, Type 2

Pycnodysostosis

Pyknodysostosis	PKND
Pycd	Toulouse-Lautrec Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160477	DC-SX029	Inhibitor	/	Unkown
HY-RS13523	SNX10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SNX10	VGNC	VGNC:77705
Bos taurus	SNX10	VGNC	VGNC:35091
Mus musculus	SNX10	MGD	MGI:1919232
Felis catus	SNX10	VGNC	VGNC:102706
Rattus norvegicus	SNX10	RGD	RGD:1305782
Canis familiaris	SNX10	VGNC	VGNC:46620

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