2. Gene
  3. GPR132 - G protein-coupled receptor 132 Gene

GPR132 - G protein-coupled receptor 132 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as G2A

Gene ID: 29933 | Gene type: protein coding

About GPR132

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,049,395-105,065,430 (from NCBI)

This gene has 6 transcripts (splice variants), 27 orthologues and 7 paralogues. Broad expression in appendix (RPKM 4.0), lymph node (RPKM 3.6) and 20 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GPR132 Products(4)

mRNA Protein Name
NM_001278694.2 NP_001265623.1 probable G-protein coupled receptor 132 isoform 1
NM_001278695.2 NP_001265624.1 probable G-protein coupled receptor 132 isoform 2
NM_001278696.2 NP_001265625.1 probable G-protein coupled receptor 132 isoform 3
NM_013345.4 NP_037477.1 probable G-protein coupled receptor 132 isoform 1

GPR132 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (60 - 308)

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  • 380 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 132

G2 accumulation protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111343 ONC212 Inducer 99.32% Unkown
HY-157189 GPR132 antagonist 1 Antagonist 99.43% Unkown
HY-157189A GPR132 antagonist 1 (dihydrocholide) Antagonist / Unkown
HY-RS05656 GPR132 Human Pre-designed siRNA Set A / Unkown
HY-119494 Commendamide / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR132 VGNC VGNC:41396
Macaca mulatta GPR132 VGNC VGNC:84343
Bos taurus GPR132 VGNC VGNC:29548
Rattus norvegicus GPR132 RGD RGD:1310817
Mus musculus GPR132 MGD MGI:1890220