2. Gene
  3. Lrrk2 - leucine-rich repeat kinase 2 Gene

Lrrk2 - leucine-rich repeat kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 300160 | Gene type: protein coding

About Lrrk2

Primary_assembly 7: 122,826,696-122,987,703 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 24.9), Spleen (RPKM 172.7) and 8 other tissues.

Summary

Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Located in several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products(1)

mRNA Protein Name
NM_001191789.2 NP_001178718.2 leucine-rich repeat serine/threonine-protein kinase 2

Lrrk2 Protein Structure

LRR_RI

LRR_RI: sd00033 (983 - 1010)

PRK15370

PRK15370: cl33128 (1009 - 1257)

LRR_RI

LRR_RI: sd00033 (1011 - 1034)

LRR_RI

LRR_RI: sd00033 (1035 - 1057)

LRR_RI

LRR_RI: sd00033 (1058 - 1082)

LRR_RI

LRR_RI: sd00033 (1083 - 1106)

LRR_RI

LRR_RI: sd00033 (1107 - 1128)

LRR_RI

LRR_RI: sd00033 (1129 - 1172)

LRR_RI

LRR_RI: sd00033 (1173 - 1195)

LRR_RI

LRR_RI: sd00033 (1196 - 1219)

LRR_RI

LRR_RI: sd00033 (1220 - 1244)

RocCOR

RocCOR: cd09914 (1332 - 1505)

COR

COR: cl24610 (1525 - 1738)

STKc_LRRK2

STKc_LRRK2: cd14068 (1882 - 2133)

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  • 2526 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100411 MLi-2 Inhibitor 99.80% Unkown
HY-13687 IKK 16 Inhibitor 98.57% Unkown
HY-10875 LRRK2-IN-1 Inhibitor 99.12% Unkown
HY-12477 PF-06447475 Inhibitor 99.94% Unkown
HY-15796 GNE0877 Inhibitor 99.15% Unkown
HY-148030 XL01126 Inhibitor 99.81% Unkown
HY-13237 GSK2578215A Inhibitor 99.78% Unkown
HY-18163 GNE-7915 Inhibitor 99.82% Unkown
HY-13488 HG-10-102-01 Inhibitor 99.34% Unkown
HY-120085 PFE-360 Inhibitor 99.48% Unkown
HY-13687A IKK 16 hydrochloride Inhibitor ≥98.0% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-B0792 CZC-54252 Inhibitor 99.38% Unkown
HY-12282 GNE-9605 Inhibitor 99.72% Unkown
HY-16936 JH-II-127 Inhibitor ≥98.0% Unkown
HY-112855 PF-06454589 Inhibitor 99.73% Unkown
HY-18163A GNE-7915 tosylate Inhibitor 99.69% Unkown
HY-40294 Indazole Inhibitor 99.72% Unkown
HY-142647 EB-42486 Inhibitor 99.62% Unkown
HY-111493 LRRK2 inhibitor 1 Inhibitor 99.93% Unkown
HY-163064 CC-3240 Inhibitor / Unkown
HY-152107 LRRK2-IN-7 Inhibitor 98.04% Unkown
HY-145317 LRRK2-IN-2 Inhibitor / Unkown
HY-153058 LRRK2-IN-8 Inhibitor / Unkown
HY-145318 LRRK2-IN-3 Inhibitor / Unkown
HY-156167 LRRK2-IN-10 Inhibitor / Unkown
HY-B0792A CZC-54252 hydrochloride Inhibitor 98.44% Unkown
HY-156429 MK-1468 Inhibitor / Unkown
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / Unkown
HY-151444 LRRK2-IN-6 Inhibitor / Unkown
HY-144074 LRRK2-IN-4 Inhibitor / Unkown
HY-148353 PF-06455943 Inhibitor / Unkown
HY-151441 LRRK2-IN-5 Inhibitor / Unkown
HY-152107A (R,R)-LRRK2-IN-7 Inhibitor / Unkown
HY-134562 PF-06371900 Inhibitor / Unkown
HY-155150 JH-XII-03-02 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrk2 NCBI NCBI:120892