2. Gene
  3. Il17a - interleukin 17A Gene

Il17a - interleukin 17A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Il17; IL-17; CTLA-8; IL-17A

Gene ID: 301289 | Gene type: protein coding

About Il17a

Primary_assembly 9: 23,144,402-23,147,889 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 97 orthologues, 4 paralogues and is associated with 105 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A). [provided by Alliance of Genome Resources, Apr 2022]

Il17a Products(1)

mRNA Protein Name
NM_001106897.1 NP_001100367.1 interleukin-17A precursor

Il17a Protein Structure

IL17

IL17: pfam06083 (71 - 149)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

interleukin-17A

Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

cytotoxic T-lymphocyte-associated antigen 8

Recombinant Il17a Proteins

Cat. No. Product Name Accession Purity
HY-P79326 IL-17A Protein, Rat (CHO) NP_001100367 (A26-S158) ≥95%
HY-P78556 IL-17A Protein, Rat NP_001100367 (A26-S158) /

Related Agents

Approval
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9927 Secukinumab Inhibitor ≥99.20% Unkown
HY-P9924 Ixekizumab Inhibitor 98.90% Unkown
HY-P99280 Bimekizumab Antagonist 95.00% Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-103637A Vimirogant hydrochloride Inhibitor 98.39% Phase 2
HY-103637 Vimirogant Inhibitor / Phase 2
HY-107390A AX-024 hydrochloride Inhibitor 99.75% Phase 1
HY-152851 Izumerogant Agonist / Phase 1
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99515 Xeligekimab Inhibitor 95.00% Phase 3
HY-P99652 Gumokimab Inhibitor / Phase 3
HY-P99563 Tibulizumab Inhibitor / Phase 3
HY-P99397 Sonelokimab Inhibitor 99.90% Phase 2
HY-P99940 Remtolumab Inhibitor 99.24% Phase 2
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15826 SGC-CBP30 Inhibitor 99.83% Unkown
HY-139206 LY3509754 Inhibitor 99.65% Unkown
HY-101913 IL-17A antagonist 1 Antagonist 99.74% Unkown
HY-107390 AX-024 Inhibitor 99.29% Yes
HY-145430 IL-17A modulator-1 Modulator 99.01% Unkown
HY-139780 JNJ-61803534 Inhibitor 99.88% Unkown
HY-145429 IL-17A modulator-2 Modulator 99.07% Unkown
HY-101915 IL-17A antagonist 3 Antagonist 98.55% Unkown
HY-119464 MRL-871 Agonist 98.18% Unkown
HY-133552 RORγt Inverse agonist 10 Antagonist 99.13% Unkown
HY-P3450 Erepdekinra Antagonist 98.60% Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-126252 A-9758 Inhibitor / Unkown
HY-130243 RORγt Inverse agonist 6 Antagonist 98.97% Unkown
HY-133128 FM26 Antagonist / Unkown
HY-139686 IL-17A inhibitor 2 Inhibitor / Unkown
HY-142939 RORγt modulator 4 Modulator / Unkown
HY-148272 IL-17A modulator-3 Modulator / Unkown
HY-153276 Androgen receptor-IN-5 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-158159 IL17A-IN-1 Inhibitor / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-N11768 4-Methoxylonchocarpin Inhibitor / Unkown
HY-RS06695 IL17A Human Pre-designed siRNA Set A / Unkown
HY-RS06696 Il17a Mouse Pre-designed siRNA Set A / Unkown
HY-RS06697 Il17a Rat Pre-designed siRNA Set A / Unkown
HY-155244 12R-LOX-IN-2 Inhibitor 99.85% Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9927A Anti-Human IL-17A Antagonist 96.32% Unkown
HY-P99310 Perakizumab Inhibitor 99.79% Unkown
HY-P99335 Vunakizumab 95.00% Unkown
HY-P99424 Afasevikumab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il17a NCBI NCBI:3605
Canis familiaris Il17a NCBI NCBI:481837
Macaca fascicularis Il17a NCBI NCBI:102119976
Mus musculus Il17a NCBI NCBI:16171
Susscrofa domestica Il17a NCBI
Leporidae Il17a NCBI
Macaca mulatta Il17a NCBI NCBI:708123