1. Gene
  2. Tert - telomerase reverse transcriptase Gene

Tert - telomerase reverse transcriptase Gene

Rattus norvegicus
Gene ID: 301965 | Gene type: protein coding

About Tert

Primary_assembly 1: 29,637,506-29,659,561 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 188 orthologues and is associated with 103 phenotypes. Biased expression in Liver (RPKM 26.6), Thymus (RPKM 16.6) and 8 other tissues.

Summary

Predicted to enable several functions, including chaperone binding activity; nucleic acid binding activity; and nucleotidyltransferase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of transdifferentiation; and positive regulation of vascular associated smooth muscle cell migration. Located in mitochondrion and nucleus. Used to study chronic kidney disease and transient cerebral ischemia. Biomarker of hepatocellular carcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase Reverse Transcriptase). [provided by Alliance of Genome Resources, Apr 2022]

Tert Products(1)

mRNA Protein Name
NM_053423.2 NP_445875.1 telomerase reverse transcriptase

Tert Protein Structure

Telomerase_RBD

Telomerase_RBD: pfam12009 (453 - 584)

TERT

TERT: cd01648 (819 - 932)

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  • 1129 a.a.
Protein Preferred Names Protein Names

telomerase reverse transcriptase

telomerase catalytic subunit

Orthologs Information

Species Symbol Source ID
Homo sapiens Tert NCBI NCBI:7015
Mus musculus Tert NCBI NCBI:21752